1K3K

Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus.

(2002) Proc Natl Acad Sci U S A 99: 3428-3433

• PubMed: 11904405 Search on PubMedSearch on PubMed Central
• DOI: https://doi.org/10.1073/pnas.062525799
• Primary Citation of Related Structures:  
  1K3K


• PubMed Abstract: 
  

  Kaposi sarcoma-associated herpes virus (KSHV) contains a gene that has functional and sequence homology to the apoptotic Bcl-2 family of proteins [Sarid, R., Sato, T., Bohenzky, R. A., Russo, J. J. & Chang, Y. (1997) Nat. Med. 3, 293-298]. The viral Bcl-2 protein promotes survival of infected cells and may contribute to the development of Kaposi sarcoma tumors [Boshoff, C. & Chang, Y. (2001) Annu. Rev. Med. 52, 453-470]. Here we describe the solution structure of the viral Bcl-2 homolog from KSHV. Comparison of the KSHV Bcl-2 structure to that of Bcl-2 and Bcl-x(L) shows that although the overall fold is the same, there are key differences in the lengths of the helices and loops. Binding studies on peptides derived from the Bcl-2 homology region 3 of proapoptotic family members indicate that the specificity of the viral protein is very different from what was previously observed for Bcl-x(L) and Bcl-2, suggesting that the viral protein has evolved to have a different mechanism of action than the host proteins.

   View More

---

Organizational Affiliation: 

Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, IL 60064, USA.