CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2
1JLC
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 116230.13
    Molecule: HIV-1 RT A-chain
    Polymer: 1 Type: protein Length: 560
    Chains: A
    EC#: 2.7.7.49    2.7.7.7    3.1.26.13   
    Fragment: p66
    Organism: HIV-1 M:B_HXB2R
    Gene Name: gag-pol
    UniProtKB: Protein Feature View | Search PDB | P04585  
    Molecule: HIV-1 RT B-chain
    Polymer: 2 Type: protein Length: 440
    Chains: B
    EC#: 2.7.7.49    2.7.7.7    3.1.26.13   
    Fragment: p51
    Organism: HIV-1 M:B_HXB2R
    Gene Name: gag-pol
    UniProtKB: Protein Feature View | Search PDB | P04585  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Hiv-1 m:b_hxb2r   Taxonomy   Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Hiv-1 m:b_hxb2r   Taxonomy   Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    1C0T   HIV-1 RT COMPLEXED WITH BM+21.1326 
    1C0U   HIV-1 RT COMPLEXED WITH BM+50.0934 
    1C1B   HIV-1 RT COMPLEXED WITH GCA-186 
    1C1C   HIV-1 RT COMPLEXED WITH TNK-6123 
    1DTQ   HIV-1 RT COMPLEXED WITH PETT-1 
    1DTT   HIV-1 RT COMPLEXED WITH PETT-2 
    1EP4   HIV-1 RT COMPLEXED WITH S-1153 
    1FK9   HIV-1 RT COMPLEXED WITH DMP-226 (EFAVIRENZ) 
    1FKO   K103N MUTANT HIV-1 RT COMPLEXED WITH DMP-226 (EFAVIRENZ) 
    1FKP   K103N MUTANT HIV-1 RT COMPLEXED WITH NEVIRAPINE 
    1JKH   Y181C MUTANT HIV-1 RT COMPLEXED WITH DMP-226 (EFAVIRENZ) 
    1JLA   Y181C MUTANT HIV-1 RT COMPLEXED TNK-651 
    1JLB   Y181C MUTANT HIV-1 RT COMPLEXED WITH NEVIRAPINE 
    1JLE   Y188C MUTANT HIV-1 RT 
    1JLF   Y188C MUTANT HIV-1 RT COMPLEXED WITH NEVIRAPINE 
    1JLG   Y188C MUTANT HIV-1 RT COMPLEXED WITH UC-781 
    1JLQ   HIV-1 RT COMPLEXED WITH 739W94 
    1KLM   HIV-1 RT COMPLEXED WITH BHAP (U-90152) 
    1REV   HIV-1 RT COMPLEXED WITH 9-CL-TIBO 
    1RT1   HIV-1 RT COMPLEXED WITH MKC-442 
    1RT2   HIV-1 RT COMPLEXED WITH TNK-651 
    1RT3   AZT DRUG RESISTANT HIV-1 RT MUTANT (RTMC) COMPLEXED WITH 1051U91 
    1RT4   HIV-1 RT COMPLEXED WITH UC-781 
    1RT5   HIV-1 RT COMPLEXED WITH UC-10 
    1RT6   HIV-1 RT COMPLEXED WITH UC-38 
    1RT7   HIV-1 RT COMPLEXED WITH UC-84 
    1RTH   HIV-1 RT COMPLEXED WITH 1051U91 
    1RTI   HIV-1 RT COMPLEXED WITH HEPT 
    1RTJ   HIV-1 RT 
    1VRT   HIV-1 RT COMPLEXED WITH NEVIRAPINE 
    1VRU   HIV-1 RT COMPLEXED WITH ALPHA-APA 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    FTC
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    FTC C15 H16 Cl F N4 O S
    N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N'- [5-CHLORO-PYRIDYL]-THIOUREA
    FTC:1JLC
     
  •   Modified Residues Hide
    Identifier Formula Parent Type
    CSD
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    CSD C3 H7 N O4 S CYS lPeptideLinking
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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