CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2     DOI:10.2210/pdb1jlc/pdb

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Primary Citation       Molecular Description Hide Classification: Transferase Structure Weight: 116230.13   Molecule: HIV-1 RT A-chain Polymer: 1 Type: polypeptide(L) Length: 560 Chains: A EC#: 2.7.7.49    Fragment: p66 Molecule: HIV-1 RT B-chain Polymer: 2 Type: polypeptide(L) Length: 440 Chains: B EC#: 2.7.7.49    Fragment: p51       Source Hide Polymer: 1 Scientific Name: Hiv-1 m:b_hxb2r Expression System: Escherichia coli   Polymer: 2 Scientific Name: Hiv-1 m:b_hxb2r Expression System: Escherichia coli         Related PDB Entries Hide Id Details 1C0T  HIV-1 RT COMPLEXED WITH BM+21.1326  1C0U  HIV-1 RT COMPLEXED WITH BM+50.0934  1C1B  HIV-1 RT COMPLEXED WITH GCA-186  1C1C  HIV-1 RT COMPLEXED WITH TNK-6123  1DTQ  HIV-1 RT COMPLEXED WITH PETT-1  1DTT  HIV-1 RT COMPLEXED WITH PETT-2  1EP4  HIV-1 RT COMPLEXED WITH S-1153  1FK9  HIV-1 RT COMPLEXED WITH DMP-226 (EFAVIRENZ)  1FKO  K103N MUTANT HIV-1 RT COMPLEXED WITH DMP-226 (EFAVIRENZ)  1FKP  K103N MUTANT HIV-1 RT COMPLEXED WITH NEVIRAPINE  1JKH  Y181C MUTANT HIV-1 RT COMPLEXED WITH DMP-226 (EFAVIRENZ)  1JLA  Y181C MUTANT HIV-1 RT COMPLEXED TNK-651  1JLB  Y181C MUTANT HIV-1 RT COMPLEXED WITH NEVIRAPINE  1JLE  Y188C MUTANT HIV-1 RT  1JLF  Y188C MUTANT HIV-1 RT COMPLEXED WITH NEVIRAPINE  1JLG  Y188C MUTANT HIV-1 RT COMPLEXED WITH UC-781  1JLQ  HIV-1 RT COMPLEXED WITH 739W94  1KLM  HIV-1 RT COMPLEXED WITH BHAP (U-90152)  1REV  HIV-1 RT COMPLEXED WITH 9-CL-TIBO  1RT1  HIV-1 RT COMPLEXED WITH MKC-442  1RT2  HIV-1 RT COMPLEXED WITH TNK-651  1RT3  AZT DRUG RESISTANT HIV-1 RT MUTANT (RTMC) COMPLEXED WITH 1051U91  1RT4  HIV-1 RT COMPLEXED WITH UC-781  1RT5  HIV-1 RT COMPLEXED WITH UC-10  1RT6  HIV-1 RT COMPLEXED WITH UC-38  1RT7  HIV-1 RT COMPLEXED WITH UC-84  1RTH  HIV-1 RT COMPLEXED WITH 1051U91  1RTI  HIV-1 RT COMPLEXED WITH HEPT  1RTJ  HIV-1 RT  1VRT  HIV-1 RT COMPLEXED WITH NEVIRAPINE  1VRU  HIV-1 RT COMPLEXED WITH ALPHA-APA        Ligand Chemical Component Hide Identifier Name Formula Interaction View Links FTC     N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N'- [5-CHLORO-PYRIDYL]-THIOUREA C15 H16 Cl F N4 O S Ligand Explorer       Modified Residues Hide Identifier Name Formula Interaction View Links CSD 3-SULFINOALANINE (parent: CYS)(type: lPeptideLinking) C3 H7 N O4 S Ligand Explorer       Derived Data Hide SCOP Classification v1.75 - (3 Domains) CATH Classification v3.2.0 - (9 Domains) PFAM Classification - (8 Domains) GO Terms - (70 Terms)     Reset Layout

Biological Assembly     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly assigned by authors and generated by PISA (software)         Deposition Summary Hide Authors:   Ren, J.,   Nichols, C.,   Bird, L.,   Chamberlain, P.,   Weaver, K.,   Short, S.,   Stuart, D.I.,   Stammers, D.K. Deposition:   2001-07-16 Release:   2001-10-03 Last Modified (REVDAT):   2009-02-24       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:    [ EDS ] Resolution[Å]: 3.00 R-Value: 0.225 (obs.) R-Free: 0.282 Space Group: P 21 21 21 Unit Cell:   Length [Å] Angles [°] a = 139.20 α = 90.00  b = 109.30 β = 90.00  c = 73.50 γ = 90.00        Structure Links Hide Molecule of the Month Features: Reverse Transcriptase