CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER     DOI:10.2210/pdb1j5o/pdb   NDB ID: PD0316

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Primary Citation       Molecular Description Hide Classification: Transferase/immune System/dna Structure Weight: 172312.52   Molecule: 5'-D(*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3' Polymer: 1 Type: polydeoxyribonucleotide Length: 19 Chains: T Molecule: 5'-D(*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*A)-3' Polymer: 2 Type: polydeoxyribonucleotide Length: 18 Chains: P Molecule: Reverse transcriptase Polymer: 3 Type: polypeptide(L) Length: 558 Chains: A EC#: 2.7.7.49    Mutation: M184I,C280S Molecule: Reverse transcriptase Polymer: 4 Type: polypeptide(L) Length: 430 Chains: B EC#: 2.7.7.49    Mutation: M184I,C280S Molecule: ANTIBODY (LIGHT CHAIN) Polymer: 5 Type: polypeptide(L) Length: 214 Chains: L Fragment: FAB28 Molecule: ANTIBODY (HEAVY CHAIN) Polymer: 6 Type: polypeptide(L) Length: 220 Chains: H Fragment: FAB28       Source Hide Polymer: 1 Scientific Name: Synthetic construct   Polymer: 2 Scientific Name: Synthetic construct   Polymer: 3 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli   Polymer: 4 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli   Polymer: 5 Scientific Name: Mus musculus Common Name: House mouse   Polymer: 6 Scientific Name: Mus musculus Common Name: House mouse         Related PDB Entries Hide Id Details 1QE1  UNLIGANDED MET184ILE HIV-1 REVERSE TRANSCRIPTASE  2HMI  WILD-TYPE HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A DOUBLE STRANDED DNA TEMPLATE-PRIMER        Derived Data Hide SCOP Classification v1.75 - (7 Domains) CATH Classification v3.2.0 - (13 Domains) PFAM Classification - (7 Domains) GO Terms - (68 Terms)     Reset Layout

Biological Assembly     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly assigned by authors         Deposition Summary Hide Authors:   Sarafianos, S.G.,   Das, K.,   Arnold, E. Deposition:   2002-05-24 Release:   2002-06-14 Last Modified (REVDAT):   2009-02-24 Previous versions: 1C9R       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:    [ EDS ] Resolution[Å]: 3.50 R-Value: 0.270 (obs.) R-Free: 0.338 Space Group: P 32 1 2 Unit Cell:   Length [Å] Angles [°] a = 169.18 α = 90.00  b = 169.18 β = 90.00  c = 221.91 γ = 120.00        Structure Links Hide Molecule of the Month Features: Reverse Transcriptase