CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA     DOI:10.2210/pdb1hys/pdb   NDB ID: PH0003

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Primary Citation       Molecular Description Hide Classification: Transferase/dna RNA Hybrid Structure Weight: 173781.63   Molecule: 5'-R(*UP*CP*AP*GP*CP*CP*AP*CP*UP*UP*UP*UP*UP*AP*AP*AP*AP*GP*AP*AP*AP*AP*G)-3' Polymer: 1 Type: polyribonucleotide Length: 23 Chains: E Molecule: 5'-D(*CP*TP*TP*TP*TP*CP*TP*TP*TP*TP*AP*AP*AP*AP*AP*GP*TP*GP*GP*CP*TP*G)-3' Polymer: 2 Type: polydeoxyribonucleotide Length: 22 Chains: F Molecule: HIV-1 REVERSE TRANSCRIPTASE Polymer: 3 Type: polypeptide(L) Length: 553 Chains: A EC#: 2.7.7.49    Fragment: P66 Mutation: C280S Molecule: HIV-1 REVERSE TRANSCRIPTASE Polymer: 4 Type: polypeptide(L) Length: 425 Chains: B EC#: 2.7.7.49    Fragment: P51 Mutation: C280S Molecule: FAB-28 MONOCLONAL ANTIBODY FRAGMENT LIGHT CHAIN Polymer: 5 Type: polypeptide(L) Length: 214 Chains: C Molecule: FAB-28 MONOCLONAL ANTIBODY FRAGMENT HEAVY CHAIN Polymer: 6 Type: polypeptide(L) Length: 220 Chains: D       Source Hide Polymer: 1 Scientific Name: Synthetic construct   Polymer: 2 Scientific Name: Synthetic construct   Polymer: 3 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli   Polymer: 4 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli   Polymer: 5 Scientific Name: Mus musculus Common Name: House mouse   Polymer: 6 Scientific Name: Mus musculus Common Name: House mouse         Related PDB Entries Hide Id Details 1DLO  Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms  1RTD  Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance  2HMI  Crystal structure of HIV-1 Reverse Transcriptase in complex with DNA:DNA        Derived Data Hide SCOP Classification v1.75 - (7 Domains) CATH Classification v3.2.0 - (13 Domains) PFAM Classification - (7 Domains) GO Terms - (68 Terms)     Reset Layout

Biological Assembly     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly assigned by authors         Deposition Summary Hide Authors:   Sarafianos, S.G.,   Das, K.,   Tantillo, C.,   Clark Jr., A.D.,   Ding, J.,   Whitcomb, J.,   Boyer, P.L.,   Hughes, S.H.,   Arnold, E. Deposition:   2001-01-22 Release:   2001-03-26 Last Modified (REVDAT):   2009-02-24       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:    [ EDS ] Resolution[Å]: 3.00 R-Value: 0.274 (work) R-Free: 0.316 Space Group: P 32 1 2 Unit Cell:   Length [Å] Angles [°] a = 166.16 α = 90.00  b = 166.16 β = 90.00  c = 218.81 γ = 120.00        Structure Links Hide Molecule of the Month Features: Reverse Transcriptase