1FL7
HUMAN FOLLICLE STIMULATING HORMONE
- PDB DOI: https://doi.org/10.2210/pdb1FL7/pdb
- Classification: HORMONE/GROWTH FACTOR
- Organism(s): Homo sapiens
- Expression System: Spodoptera frugiperda
- Mutation(s): Yes
- Deposited: 2000-08-11 Released: 2001-03-14
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 3.00 Å
- R-Value Free: 0.294
- R-Value Work: 0.259
wwPDB Validation 3D Report Full Report
This is version 2.1 of the entry. See complete history.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| FOLLICLE STIMULATING PROTEIN ALPHA CHAIN | 92 | Homo sapiens | Mutation(s): 0 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P01215 (Homo sapiens) Explore P01215 Go to UniProtKB: P01215 | |||||
PHAROS: P01215 GTEx: ENSG00000135346 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P01215 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| FOLLICLE STIMULATING PROTEIN BETA CHAIN | 111 | Homo sapiens | Mutation(s): 1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P01225 (Homo sapiens) Explore P01225 Go to UniProtKB: P01225 | |||||
PHAROS: P01225 GTEx: ENSG00000131808 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P01225 | ||||
Sequence AnnotationsExpand | |||||
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Oligosaccharides
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
| 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | E, H | 2 |  | N-Glycosylation | |
Glycosylation Resources | |||||
GlyTouCan: G07375KG GlyCosmos: G07375KG GlyGen: G07375KG | |||||
Entity ID: 4 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
| alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | F | 3 |  | N-Glycosylation | |
Glycosylation Resources | |||||
GlyTouCan: G62182OO GlyCosmos: G62182OO GlyGen: G62182OO | |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| SO4 Query on SO4 | K [auth B], L [auth D] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 3.00 Å
- R-Value Free: 0.294
- R-Value Work: 0.259
- Space Group: P 41 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 128.3 | α = 90 |
| b = 128.3 | β = 90 |
| c = 155.22 | γ = 90 |
| Software Name | Purpose |
|---|---|
| MOSFLM | data reduction |
| SCALA | data scaling |
| SOLVE | phasing |
| CNS | refinement |
| CCP4 | data scaling |
Entry History
Deposition Data
- Released Date: 2001-03-14 Deposition Author(s): Fox, K.M., Dias, J.A., Van Roey, P.
Revision History (Full details and data files)
- Version 1.0: 2001-03-14
Type: Initial release - Version 1.1: 2008-04-27
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Non-polymer description, Version format compliance - Version 1.3: 2018-01-31
Changes: Experimental preparation - Version 2.0: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Advisory, Atomic model, Data collection, Derived calculations, Structure summary - Version 2.1: 2021-11-03
Changes: Database references, Structure summary
