CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)     DOI:10.2210/pdb1fk9/pdb

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Primary Citation       Molecular Description Hide Classification: Transferase Structure Weight: 114499.88   Molecule: HIV-1 RT, A-CHAIN Polymer: 1 Type: polypeptide(L) Length: 543 Chains: A EC#: 2.7.7.49    Fragment: P66 Other Details: COMPLEXED WITH DMP-266(EFAVIRENZ) Molecule: HIV-1 RT, B-CHAIN Polymer: 2 Type: polypeptide(L) Length: 440 Chains: B EC#: 2.7.7.49    Fragment: P51       Source Hide Polymer: 1 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli   Polymer: 2 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli         Related PDB Entries Hide Id Details 1c0t  HIV-1 RT complexed with BM+21.1326  1c0u  HIV-1 RT complexed with BM+50.0934  1c1b  HIV-1 RT complexed with GCA-186  1c1c  HIV-1 RT complexed with TNK-6123  1dtq  HIV-1 RT complexed with PETT-1  1dtt  HIV-1 RT complexed with PETT-2  1ep4  HIV-1 RT complexed with S-1153  1klm  HIV-1 RT complexed with BHAP (U-90152)  1rev  HIV-1 RT complexed with 9-Cl-TIBO  1rt1  HIV-1 RT complexed with MKC-442  1rt2  HIV-1 RT complexed with TNK-651  1rt3  AZT drug resistant HIV-1 RT mutant (RTMC) complexed with 1051U91  1rt4  HIV-1 RT complexed with UC-781  1rt5  HIV-1 RT complexed with UC-10  1rt6  HIV-1 RT complexed with UC-38  1rt7  HIV-1 RT complexed with UC-84  1rth  HIV-1 RT complexed with 1051U91  1rti  HIV-1 RT complexed with HEPT  1rtj  HIV-1 RT  1rtv  HIV-1 RT complexed with nevirapine  1vru  HIV-1 RT complexed with alpha-APA        Ligand Chemical Component Hide Identifier Name Formula Interaction View Links EFZ     (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL- 1,4-DIHYDRO-2H-3,1 -BENZOXAZIN-2-ONE C14 H9 Cl F3 N O2 Ligand Explorer       Modified Residues Hide Identifier Name Formula Interaction View Links CSD 3-SULFINOALANINE (parent: CYS)(type: lPeptideLinking) C3 H7 N O4 S Ligand Explorer       Derived Data Hide SCOP Classification v1.75 - (3 Domains) CATH Classification v3.2.0 - (9 Domains) PFAM Classification - (8 Domains) GO Terms - (70 Terms)     Reset Layout

Biological Assembly     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly assigned by authors and generated by PISA (software)         Deposition Summary Hide Authors:   Ren, J.,   Milton, J.,   Weaver, K.L.,   Short,   S.A,   Stuart, D.I.,   Stammers, D.K. Deposition:   2000-08-09 Release:   2000-11-03 Last Modified (REVDAT):   2009-02-24       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:    [ EDS ] Resolution[Å]: 2.50 R-Value: 0.214 (obs.) R-Free: 0.301 Space Group: P 21 21 21 Unit Cell:   Length [Å] Angles [°] a = 139.80 α = 90.00  b = 115.00 β = 90.00  c = 65.40 γ = 90.00        Structure Links Hide Molecule of the Month Features: Reverse Transcriptase