Download MendeleyProtein-protein recognition, hydride transfer and proton pumping in the transhydrogenase complex.
Buckley, P.A., Baz Jackson, J., Schneider, T., White, S.A., Rice, D.W., Baker, P.J.(2000) Structure 8: 809-815
- PubMed: 10997900
- DOI: https://doi.org/10.1016/s0969-2126(00)00171-4
- Primary Citation of Related Structures:
1F8G - PubMed Abstract:
Membrane-bound ion pumps are involved in metabolic regulation, osmoregulation, cell signalling, nerve transmission and energy transduction. How the ion electrochemical gradient interacts with the scalar chemistry and how the catalytic machinery is gated to ensure high coupling efficiency are fundamental to the mechanism of action of such pumps. Transhydrogenase is a conformationally coupled proton pump linking a proton gradient to the redox reaction between NAD(H) and NADP(H). The enzyme has three components; dI binds NAD(H), dII spans the membrane and dIII binds NADP(H).
Organizational Affiliation:
Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, UK.
