1EOT

SOLUTION NMR STRUCTURE OF EOTAXIN, MINIMIZED AVERAGE STRUCTURE


Experimental Data Snapshot

  • Method: SOLUTION NMR
  • Conformers Calculated: 40 
  • Conformers Submitted: 
  • Selection Criteria: STRUCTURES WERE SELECTED WITH NO VIOLATIONS > 0.3 A OR DIHEDRAL ANGLES > 0.5 A AND GOOD COVALENT GEOMETRY. 

wwPDB Validation   3D Report Full Report

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This is version 1.3 of the entry. See complete history


Literature

Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation.

Crump, M.P.Rajarathnam, K.Kim, K.S.Clark-Lewis, I.Sykes, B.D.

(1998) J Biol Chem 273: 22471-22479

  • DOI: https://doi.org/10.1074/jbc.273.35.22471
  • Primary Citation of Related Structures:  
    1EOT, 2EOT

  • PubMed Abstract: 

    The solution structure of the CCR3-specific chemokine, eotaxin, has been determined by NMR spectroscopy. The quaternary structure of eotaxin was investigated by ultracentrifugation and NMR, and it was found to be in equilibrium between monomer and dimer under a wide range of conditions. At pH


  • Organizational Affiliation

    Protein Engineering Network of Centres of Excellence (PENCE) and Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2S2.


Macromolecules
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
EOTAXIN74Homo sapiensMutation(s): 0 
UniProt & NIH Common Fund Data Resources
Find proteins for P51671 (Homo sapiens)
Explore P51671 
Go to UniProtKB:  P51671
PHAROS:  P51671
GTEx:  ENSG00000172156 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP51671
Sequence Annotations
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: SOLUTION NMR
  • Conformers Calculated: 40 
  • Conformers Submitted: 
  • Selection Criteria: STRUCTURES WERE SELECTED WITH NO VIOLATIONS > 0.3 A OR DIHEDRAL ANGLES > 0.5 A AND GOOD COVALENT GEOMETRY. 

Structure Validation

View Full Validation Report

Currently 1EOT does not have a validation slider image.



Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 1999-01-13
    Type: Initial release
  • Version 1.1: 2008-03-24
    Changes: Version format compliance
  • Version 1.2: 2011-07-13
    Changes: Version format compliance
  • Version 1.3: 2022-02-16
    Changes: Data collection, Database references, Derived calculations, Experimental preparation, Other