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HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN
1EFN
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Complex (sh3 Domain/viral Enhancer)
    Structure Weight: 49427.49
    Molecule: FYN TYROSINE KINASE
    Polymer: 1 Type: protein Length: 59
    Chains: A, C
    EC#: 2.7.10.2   
    Fragment: SH3 DOMAIN, RESIDUES 85-141
    Mutation: R96I
    Organism: Homo sapiens
    Gene Name: Gene View for FYN
    UniProtKB: Protein Feature View | Search PDB | P06241  
    Molecule: HIV-1 NEF PROTEIN
    Polymer: 2 Type: protein Length: 152
    Chains: B, D
    Fragment: CONSERVED CORE DOMAIN OF NEF, RESIDUES 71-203
    Mutation: T71R
    Organism: Human immunodeficiency virus 1
    Gene Name: nef
    UniProtKB: Protein Feature View | Search PDB | P03406  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli bl21(de3)  
    Polymer: 2
    Scientific Name: Human immunodeficiency virus 1   Taxonomy   Expression System: Escherichia coli  
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    PBM
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    PBM C3 H9 Pb
    TRIMETHYL LEAD ION
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors
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  •   Deposition Summary Hide
    Authors:   Lee, C.-H.,  Kuriyan, J.

    Deposition:   1996-06-29
    Release:   1997-01-11
    Last Modified (REVDAT):   2009-02-24
     
  •   Revision History    Hide
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   2.50
    R-Value: 0.215 (obs.)
    R-Free: 0.282
    Space Group: P 65 2 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 107.80 α = 90.00 
    b = 107.80 β = 90.00 
    c = 229.10 γ = 120.00