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STRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE
 
 
DOI:10.2210/pdb1daz/pdb
1DAZ
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Hydrolase
    Structure Weight: 23117.69
     
    Molecule:HIV-1 PROTEASE (RETROPEPSIN)
    Polymer:1Type:polypeptide(L)Length:99
    Chains:C, D
    EC#:3.4.23.16 Go to IUBMB EC entry  
    Mutation:Q7K, L33I, L63I, C67A, C95A, K45I
    Molecule:PEPTIDE INHIBITOR
    Polymer:2Type:polypeptide(L)Length:7
    Chains:A, B
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Human immunodeficiency virus 1 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Synthetic construct Go to NCBI Taxonomy entry  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1A94  1A94 IS THE STRUCTURE OF THE HIV-1 PROTEASE WITH MUTATIONS Q7K, L33I, L63I, C67A, C95A, WHICH STABILIZE THE PROTEASE FROM AUTOPROTEOLYSIS, WHILE RETAINING ACTIVITY SIMILAR TO WILD TYPE HIV-1 PROTEASE. THIS MUTANT (K45I) ALSO HAS THE ABOVE MUTATIONS TO PREVENT AUTOPROTEOLYSIS. 
     
     
  •  
    Move Section Modified Residues Hide
    Identifier Name Formula Interaction View Links
    NLE NORLEUCINE (parent: LEU)(type: lPeptideLinking) C6 H13 N O2 3D Ligand Explorer Link out to Ligand Expos:NLE Link out to SuperLigands:NLE Link out to SuperHapten:NLE 2D
     
     
  •  
    Move Section Derived Data Hide
     
     
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  •  
    Move Section Deposition Summary Hide
    Authors:   Mahalingam, B.,   M Louis, J.,   Reed, C.C.,   Adomat, J.M.,   Krouse, J.,   Wang, Y.F.,   W Harrison, R.,   Weber, I.T.

    Deposition:   1999-11-01
    Release:   2000-05-03
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   Download Structure Factors  [ EDS External Link to EDS ]
    View a histogram of Resolution Resolution[Å]: 1.55
    R-Value: 0.213 (obs.)
    R-Free: 0.256
    Space Group: P 21 21 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 51.24 α = 90.00 
    b = 58.19 β = 90.00 
    c = 61.22 γ = 90.00