POP-OUT | CLOSE
 
HIV-1 PROTEASE V82F/I84V DOUBLE MUTANT/TIPRANAVIR COMPLEX
1D4S
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Hydrolase
    Structure Weight: 22278.47
    Molecule: PROTEIN (HIV-1 PROTEASE)
    Polymer: 1 Type: protein Length: 99
    Chains: A, B
    EC#: 3.4.23.16   
    Mutation: V82F, I84V
    Organism: Human immunodeficiency virus 1
    Gene Name: gag-pol
    UniProtKB: Protein Feature View | Search PDB | P03367  
     
  •   Structure Validation Hide

    Download full validation report    

     

  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Human immunodeficiency virus 1   Taxonomy   Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    1D4Y   
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    TPV
    Search 
    Download 
    TPV C31 H33 F3 N2 O5 S
    N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL- 6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)- 5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE
    TPV:1D4S
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    TPV
    Search 
    Download 
    TPV
    Ki: 0.008 - 0.032 nM (96) - data from BindingDB  
    Ki: 0.008 nM - data from BindingMOAD  
    N/Ain PDBbind
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
Downloadable viewers:
 
 
 
  •   MyPDB Personal Annotations Hide
     
  •   Deposition Summary Hide
    Authors:   Watenpaugh, K.D.,  Janakiraman, M.N.

    Deposition:   1999-10-05
    Release:   1999-10-12
    Last Modified (REVDAT):   2012-02-22
     
  •   Revision History    Hide
    Mouse over text for details
    2012-02-22
    Citation
    2011-07-13
    Version format compliance
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
    N/A
    Resolution[Å]:   2.50
    R-Value: 0.179 (all)
    R-Free: 0.294
    Space Group: P 21 21 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 58.73 α = 90.00 
    b = 86.68 β = 90.00 
    c = 46.21 γ = 90.00