Download MendeleyThe structure of TolB, an essential component of the tol-dependent translocation system, and its protein-protein interaction with the translocation domain of colicin E9.
Carr, S., Penfold, C.N., Bamford, V., James, R., Hemmings, A.M.(2000) Structure 8: 57-66
- PubMed: 10673426
- DOI: https://doi.org/10.1016/s0969-2126(00)00079-4
- Primary Citation of Related Structures:
1C5K - PubMed Abstract:
E colicin proteins have three functional domains, each of which is implicated in one of the stages of killing Escherichia coli cells: receptor binding, translocation and cytotoxicity. The central (R) domain is responsible for receptor-binding activity whereas the N-terminal (T) domain mediates translocation, the process by which the C-terminal cytotoxic domain is transported from the receptor to the site of its cytotoxicity. The translocation of enzymatic E colicins like colicin E9 is dependent upon TolB but the details of the process are not known.
Organizational Affiliation:
Colicin Research Group, School of Biological Sciences, School of Chemical Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.
