Download MendeleyNMR solution structure of a peptide nucleic acid complexed with RNA.
Brown, S.C., Thomson, S.A., Veal, J.M., Davis, D.G.(1994) Science 265: 777-780
- PubMed: 7519361
- DOI: https://doi.org/10.1126/science.7519361
- Primary Citation of Related Structures:
176D - PubMed Abstract:
Peptide nucleic acids (PNA) incorporating nucleic acid bases into an achiral polyamide backbone bind to DNA in a sequence-dependent manner. The structure of a PNA-ribonucleic acid (RNA) complex was determined with nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex with a complementary RNA that is an antiparallel, right-handed double helix with Watson-Crick base pairing similar to the "A" form structure of RNA duplexes. The achiral PNA backbone assumed a distinct conformation upon binding that differed from previously proposed models and provides a basis for further structure-based design of antisense agents.
Organizational Affiliation:
Glaxo Research Institute, Research Triangle Park, NC 27709.
