4UYI

Crystal structure of the BTB domain of human SLX4 (BTBD12)

PDB DOI: https://doi.org/10.2210/pdb4UYI/pdb

Classification: HYDROLASE
Organism(s): Homo sapiens
Expression System: Escherichia coli BL21
Mutation(s): Yes

Deposited: 2014-09-01 Released: 2014-10-01
Deposition Author(s): Pinkas, D.M., Sanvitale, C.E., Strain-Damerell, C., Fairhead, M., Wang, D., Tallant, C., Cooper, C.D.O., Sorrell, F.J., Kopec, J., Chaikuad, A., Fitzpatrick, F., Pike, A.C.W., Hozjan, V., Ying, Z., Roos, A.K., Savitsky, P., Bradley, A., Nowak, R., Filippakopoulos, P., Krojer, T., Burgess-Brown, N.A., Marsden, B.D., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.

Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 1.86 Å
R-Value Free: 0.194
R-Value Work: 0.180
R-Value Observed: 0.180

wwPDB Validation 3D Report Full Report

This is version 1.2 of the entry. See complete history.

Literature

Crystal Structure of the Btb Domain of Human Slx4 (Btbd12)

Pinkas, D.M., Sanvitale, C.E., Strain-Damerell, C., Fairhead, M., Wang, D., Tallant, C., Cooper, C.D.O., Sorrell, F.J., Kopec, J., Chaikuad, A., Fitzpatrick, F., Pike, A.C.W., Hozjan, V., Ying, Z., Roos, A.K., Savitsky, P., Bradley, A., Nowak, R., Filippakopoulos, P., Krojer, T., Burgess-Brown, N.A., Marsden, B.D., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.

To be published.

Macromolecule Content

Total Structure Weight: 16.74 kDa
Atom Count: 1,071
Modelled Residue Count: 127
Deposited Residue Count: 152
Unique protein chains: 1

Macromolecules

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4	A	152	Homo sapiens	Mutation(s): 2
UniProt & NIH Common Fund Data Resources
Find proteins for Q8IY92 (Homo sapiens) Explore Q8IY92 Go to UniProtKB: Q8IY92
PHAROS: Q8IY92 GTEx: ENSG00000188827
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	Q8IY92
Sequence Annotations Expand
Reference Sequence

Experimental Data & Validation

Experimental Data

Method: X-RAY DIFFRACTION
Resolution: 1.86 Å
R-Value Free: 0.194
R-Value Work: 0.180
R-Value Observed: 0.180
Space Group: H 3 2

Unit Cell:

Length ( Å )	Angle ( ˚ )
a = 142.49	α = 90
b = 142.49	β = 90
c = 50.93	γ = 120

Software Package:

Software Name	Purpose
PHENIX	refinement
XDS	data reduction
XDS	data scaling
MR-Rosetta	phasing

Structure Validation

View Full Validation Report

Entry History

Deposition Data

Released Date: 2014-10-01

Deposition Author(s):

Sanvitale, C.E.

Strain-Damerell, C.

Fitzpatrick, F.

Filippakopoulos, P.

Burgess-Brown, N.A.

Arrowsmith, C.H.

Revision History (Full details and data files)

Version 1.0: 2014-10-01
Type: Initial release
Version 1.1: 2014-10-15
Changes: Atomic model
Version 1.2: 2018-01-24
Changes: Database references, Structure summary

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.