Download MendeleyA single amino-acid dictates the dynamics of the switch between active and inactive C-src conformation
Boubeva, R., Pernot, L., Cristiani, A., Moretti, L., Berteotti, A., Perozzo, R., Gervasio, F., Scapozza, L.To be published.
3QLF
Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with pyrazolopyrimidine 5
- PDB DOI: https://doi.org/10.2210/pdb3QLF/pdb
- Classification: TRANSFERASE
- Organism(s): Gallus gallus
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2011-02-02 Released: 2012-02-08
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.75 Å
- R-Value Free: 0.232
- R-Value Work: 0.192
- R-Value Observed: 0.194
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Proto-oncogene tyrosine-protein kinase Src | 286 | Gallus gallus | Mutation(s): 1 Gene Names: SRC EC: 2.7.10.2 |  | |
UniProt | |||||
Find proteins for P00523 (Gallus gallus) Explore P00523 Go to UniProtKB: P00523 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P00523 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PD5 Query on PD5 | C [auth A], D [auth B] | 1-{4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea C22 H20 F3 N7 O LEERPLGXOHLQPF-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.75 Å
- R-Value Free: 0.232
- R-Value Work: 0.192
- R-Value Observed: 0.194
- Space Group: P 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 42.268 | α = 79.48 |
| b = 63.495 | β = 90.09 |
| c = 73.451 | γ = 89.41 |
| Software Name | Purpose |
|---|---|
| PHASER | phasing |
| PHENIX | refinement |
| MOSFLM | data reduction |
| SCALA | data scaling |
Entry History
Deposition Data
- Released Date: 2012-02-08 Deposition Author(s): Boubeva, R., Pernot, L., Perozzo, R., Scapozza, L.
Revision History (Full details and data files)
- Version 1.0: 2012-02-08
Type: Initial release - Version 1.1: 2023-09-13
Changes: Data collection, Database references, Derived calculations, Refinement description
