Download MendeleyThe Discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors.
Buckmelter, A.J., Ren, L., Laird, E.R., Rast, B., Miknis, G., Wenglowsky, S., Schlachter, S., Welch, M., Tarlton, E., Grina, J., Lyssikatos, J., Brandhuber, B.J., Morales, T., Randolph, N., Vigers, G., Martinson, M., Callejo, M.(2011) Bioorg Med Chem Lett 21: 1248-1252
- PubMed: 21211972
- DOI: https://doi.org/10.1016/j.bmcl.2010.12.039
- Primary Citation of Related Structures:
3PSB - PubMed Abstract:
Virtual and high-throughput screening identified imidazo[1,2-a]pyrazines as inhibitors of B-Raf. We describe the rationale, SAR, and evolution of the initial hits to a series of furo[2,3-c]pyridine indanone oximes as highly potent and selective inhibitors of B-Raf.
Organizational Affiliation:
Array BioPharma, 3200 Walnut Street, Boulder, CO 80301, USA.
