Download MendeleyCrystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207
Fedorov, A.A., Fedorov, E.V., Pauletti, D., Meyer, S.L., Hudkins, R.L., Almo, S.C.To be published.
3L8P
Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207
- PDB DOI: https://doi.org/10.2210/pdb3L8P/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2010-01-03 Released: 2010-10-06
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.40 Å
- R-Value Free: 0.265
- R-Value Work: 0.238
- R-Value Observed: 0.238
This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Angiopoietin-1 receptor | 317 | Homo sapiens | Mutation(s): 0 Gene Names: TEK, TIE2 EC: 2.7.10.1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q02763 (Homo sapiens) Explore Q02763 Go to UniProtKB: Q02763 | |||||
PHAROS: Q02763 GTEx: ENSG00000120156 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q02763 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 0CE Query on 0CE | B [auth A] | 2-methyl-11-(1-methylethyl)-8-[(2S)-tetrahydro-2H-pyran-2-yl]-2,11,12,13-tetrahydro-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one C28 H28 N4 O2 JPKZOLAMWIKKME-QHCPKHFHSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.40 Å
- R-Value Free: 0.265
- R-Value Work: 0.238
- R-Value Observed: 0.238
- Space Group: P 42 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 85.602 | α = 90 |
| b = 85.602 | β = 90 |
| c = 107.344 | γ = 90 |
| Software Name | Purpose |
|---|---|
| ADSC | data collection |
| EPMR | phasing |
| CNS | refinement |
| DENZO | data reduction |
| SCALEPACK | data scaling |
Entry History
Deposition Data
- Released Date: 2010-10-06 Deposition Author(s): Fedorov, A.A., Fedorov, E.V., Pauletti, D., Meyer, S.L., Hudkins, R.L., Almo, S.C.
Revision History (Full details and data files)
- Version 1.0: 2010-10-06
Type: Initial release - Version 1.1: 2011-07-13
Changes: Version format compliance - Version 1.2: 2023-09-06
Changes: Data collection, Database references, Derived calculations, Refinement description
