Download MendeleyKinase domain of human ephrin type-a receptor 7 (epha7) in complex with ALW-II-49-7
Walker, J.R., Syeda, F., Gray, N., Butler-Cole, C., Bountra, C., Wolkstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S.To be published.
3DKO
Complex between the kinase domain of human ephrin type-a receptor 7 (epha7) and inhibitor alw-ii-49-7
- PDB DOI: https://doi.org/10.2210/pdb3DKO/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2008-06-25 Released: 2008-08-19
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.232
- R-Value Work: 0.189
- R-Value Observed: 0.191
This is version 1.3 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Ephrin type-A receptor 7 | 318 | Homo sapiens | Mutation(s): 0 Gene Names: EPHA7, EHK3, HEK11 EC: 2.7.10.1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q15375 (Homo sapiens) Explore Q15375 Go to UniProtKB: Q15375 | |||||
PHAROS: Q15375 GTEx: ENSG00000135333 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q15375 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| IHZ Query on IHZ | B [auth A] | 5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide C21 H17 F3 N4 O2 SAAYRHKJHDIDPH-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.232
- R-Value Work: 0.189
- R-Value Observed: 0.191
- Space Group: P 65
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 52.658 | α = 90 |
| b = 52.658 | β = 90 |
| c = 217.059 | γ = 120 |
| Software Name | Purpose |
|---|---|
| PHASER | phasing |
| REFMAC | refinement |
| SBC-Collect | data collection |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
Entry History
Deposition Data
- Released Date: 2008-08-19 Deposition Author(s): Walker, J.R., Syeda, F., Gray, N., Butler-Cole, C., Bountra, C., Wolkstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Revision History (Full details and data files)
- Version 1.0: 2008-08-19
Type: Initial release - Version 1.1: 2011-07-13
Changes: Version format compliance - Version 1.2: 2017-10-25
Changes: Refinement description - Version 1.3: 2023-08-30
Changes: Data collection, Database references, Derived calculations, Refinement description
