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An Information Portal to 105212 Biological Macromolecular Structures

Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (FabG)(G92A) from Vibrio cholerae
Biology and Chemistry Report
3TZK
  •   Structure Details   Hide

    Structure Keywords

    Keywords OXIDOREDUCTASE
    Text Vibrio cholerae, 3-ketoacyl-(acyl-carrier-protein) reductase, FabG, OXIDOREDUCTASE, Structural Genomics, Center for Structural Genomics of Infectious Diseases, CSGID

    Polymeric Molecules

    Chain A,B
    Description 3-oxoacyl-[acyl-carrier protein] reductase 
    Mutation G92A 
    Nonstandard Linkage no 
    Nonstandard Monomers no 
    Polymer Type polypeptide(L) 
    Formula Weight 26372.3 
    Source Method genetically manipulated  

    Ligands and Prosthetic Groups

    ID Name Chemical Formula Weight Ligand Structure
    SO4  SULFATE ION  O4 S   96.06  View 
    UNX  UNKNOWN ATOM OR ION  X   0.00  View 
     
  •   Protein Details   Hide

    UniProtKB Information

    Chain SWS/UNP ID SWS/UNP Accession(s)
    A,B C3NP04_VIBCJ C3NP04     

    Keywords and Names

    Chain(s) RCSB Name UniProtKB Name UniProtKB Keywords

    EC, Associated Pathways and Catalytic Sites

    Chain(s) IUBMB KEGG BioCyc
    A B  1.1.1.100      
    C: Cellular Location | F: Molecular Function | P: Biological Process
    Chain A,B
    GO ID   Ontology GO Term Definition
    6633   Fatty Acid Biosynthetic Process  The Chemical Reactions and Pathways Resulting in the Formation of a Fatty Acid Any of the Aliphatic Monocarboxylic Acids That Can Be Liberated by Hydrolysis From Naturally Occurring Fats and Oils. Fatty Acids Are Predominantly Straight Chain Acids of 4 to 24 Carbon Atoms Which May Be Saturated or Unsaturated; Branched Fatty Acids and Hydroxy Fatty Acids Also Occur and Very Long Chain Acids of Over 30 Carbons Are Found in Waxes. 
    8152   Metabolic Process  The Chemical Reactions and Pathways Including Anabolism and Catabolism by Which Living Organisms Transform Chemical Substances. Metabolic Processes Typically Transform Small Molecules But Also Include Macromolecular Processes Such As DNA Repair and Replication and Protein Synthesis and Degradation. 
    55114   Oxidation Reduction Process  A Metabolic Process That Results in the Removal or Addition of One or More Electrons to or From a Substance with or Without the Concomitant Removal or Addition of a Proton or Protons. 
    166   Nucleotide Binding  Interacting Selectively and Non Covalently with a Nucleotide Any Compound Consisting of a Nucleoside That Is Esterified with (ortho)phosphate or an Oligophosphate At Any Hydroxyl Group On the Ribose or Deoxyribose. 
    4316   3 Oxoacyl [acyl Carrier Protein] Reductase (nadph) Activity  Catalysis of the Reaction: (3r) 3 Hydroxyacyl [acyl Carrier Protein] + Nadp+ = 3 Oxoacyl [acyl Carrier Protein] + Nadph + H+. 
    16491   Oxidoreductase Activity  Catalysis of an Oxidation Reduction (redox) Reaction a Reversible Chemical Reaction in Which the Oxidation State of an Atom or Atoms Within a Molecule Is Altered. One Substrate Acts As a Hydrogen or Electron Donor and Becomes Oxidized While the Other Acts As Hydrogen or Electron Acceptor and Becomes Reduced. 
    51287   NAD Binding  Interacting Selectively and Non Covalently with Nicotinamide Adenine Dinucleotide a Coenzyme Involved in Many Redox and Biosynthetic Reactions; Binding May Be to Either the Oxidized Form Nad+ or the Reduced Form Nadh. 


     
  •   Gene Details   Hide

    Genetic Source

    Chain A,B
    Scientific Name Vibrio cholerae  
    Strain MJ-1236
    Gene vc2021, vcd_002346
    Host Scientific Name Escherichia coli  
    Host Strain Bl21 Codonplus(de3) Ripl
    Host Vector Type Plasmid
    Host Plasmid Name pMCSG7