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An Information Portal to 105097 Biological Macromolecular Structures

THE FOURTH FAS1 DOMAIN STRUCTURE OF HUMAN BIGH3
Biology and Chemistry Report
2VXP
  •   Structure Details   Hide

    Structure Keywords

    Keywords CELL ADHESION
    Text RGD-CONTAINING COLLAGEN-ASSOCIATED PROTEIN, FAS1, BIGH3, VISION, AMYLOID, RGD-CAP, SECRETED, DISEASE MUTATION, KERATO-EPITHELIN, FASCICLIN 1, CELL ADHESION, SENSORY TRANSDUCTION, EXTRACELLULAR MATRIX

    Polymeric Molecules

    Chain A,B
    Description TRANSFORMING GROWTH FACTOR-BETA-INDUCED PROTEIN IG-H3 
    Fragment FOURTH FAS1 DOMAIN, RESIDUES 502-633 
    Nonstandard Linkage no 
    Nonstandard Monomers no 
    Polymer Type polypeptide(L) 
    Formula Weight 14256.6 
    Source Method genetically manipulated  
    Entity Name BETA IG-H3, KERATO-EPITHELIN, RGD-CONTAINING COLLAGEN-ASSOCIATED PROTEIN, RGD-CAP 

     
  •   Protein Details   Hide

    UniProtKB Information

    Chain SWS/UNP ID SWS/UNP Accession(s)
    A,B BGH3_HUMAN D3DQB1     

    Keywords and Names

    Chain(s) RCSB Name UniProtKB Name UniProtKB Keywords

     
  •   Gene Details   Hide

    Genetic Source

    Chain A,B
    Common Name Human
    Scientific Name Homo sapiens  
    Host Scientific Name Escherichia coli  
    Host Strain Bl21(de3)
    Host Vector Prset(a)


    Genome Information

    Chromosome Locus Gene ID Gene Name Symbol
    5 5q31 7045     transforming growth factor, beta-induced, 68kDa TGFBI    

    Single Nucleotide Polymorphisms (from LS-SNP database)

    SNP ID LsSnp Link dbSNP Link Chain PDB position Amino acid changes Secondary structure Solvent Accessibility Chromosome Chromosome position Ligand
    rs188677757 LS-SNP   dbSNP   A 502 M - > V Coil 98% (Exposed) 5 135391462
    rs201775031 LS-SNP   dbSNP   A 505 V - > I Helix 0% (Buried) 5 135391471
    rs121909216 LS-SNP   dbSNP   A 509 L - > R Helix 1% (Buried) 5 135391484
    rs73296968 LS-SNP   dbSNP   A 514 R - > H Turn 43% (Exposed) 5 135391499
    rs200065806 LS-SNP   dbSNP   A 514 R - > C Turn 43% (Exposed) 5 135391498
    rs121909214 LS-SNP   dbSNP   A 540 F - > S Beta Ladder 0% (Buried) 5 135392425
    rs138125037 LS-SNP   dbSNP   A 548 R - > Q Helix 75% (Exposed) 5 135392449
    rs202066916 LS-SNP   dbSNP   A 549 A - > T Helix 54% (Exposed) 5 135392451
    rs121909208 LS-SNP   dbSNP   A 555 R - > W Helix 45% (Exposed) 5 135392469
    rs121909209 LS-SNP   dbSNP   A 555 R - > Q Helix 45% (Exposed) 5 135392470
    rs200219644 LS-SNP   dbSNP   A 559 L - > W Helix 34% (Intermediate) 5 135392482
    rs200887459 LS-SNP   dbSNP   A 581 G - > R Turn 76% (Exposed) 5 135394841
    rs199579539 LS-SNP   dbSNP   A 598 E - > V Beta Ladder 35% (Intermediate) 5 135394893
    rs121909215 LS-SNP   dbSNP   A 623 G - > D Beta Ladder 14% (Intermediate) 5 135396587
    rs200201691 LS-SNP   dbSNP   A 624 V - > M Beta Ladder 1% (Buried) 5 135396589