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Crystal structure of the ankyrin repeat domain of the TRPV2
Biology and Chemistry Report
2ETA
  •   Structure Details   Hide

    Structure Keywords

    Keywords TRANSPORT PROTEIN
    Text TRPV2, ankyrin repeat domain, TRANSPORT PROTEIN

    Polymeric Molecules

    Chain A,B
    Description Transient receptor potential cation channel subfamily V member 2 
    Fragment residues 75-321 
    Nonstandard Linkage no 
    Nonstandard Monomers no 
    Polymer Type polypeptide(L) 
    Formula Weight 28533.8 
    Source Method genetically manipulated  
    Entity Name TrpV2, osm-9-like TRP channel 2, OTRPC2, Vanilloid receptor-like protein 1, VRL-1, Stretch-activated channel 2B 

     
  •   Protein Details   Hide

    UniProtKB Information

    Chain SWS/UNP ID SWS/UNP Accession(s)
    A,B TRPV2_RAT Q5FWT3     

    Keywords and Names

    Chain(s) RCSB Name UniProtKB Name UniProtKB Keywords

    C: Cellular Location | F: Molecular Function | P: Biological Process
    Chain A,B
    GO ID   Ontology GO Term Definition
    6811   Ion Transport  The Directed Movement of Charged Atoms or Small Charged Molecules Into Out of or Within a Cell or Between Cells by Means of Some Agent Such As a Transporter or Pore. 
    9408   Response to Heat  Any Process That Results in a Change in State or Activity of a Cell or an Organism (in Terms of Movement Secretion Enzyme Production Gene Expression Etc.) As a Result of a Heat Stimulus a Temperature Stimulus Above the Optimal Temperature For That Organism. 
    70588   Calcium Ion Transmembrane Transport  A Process in Which a Calcium Ion Is Transported From One Side of a Membrane to the Other by Means of Some Agent Such As a Transporter or Pore. 
    5622   Intracellular  The Living Contents of a Cell; the Matter Contained Within (but Not Including) the Plasma Membrane Usually Taken to Exclude Large Vacuoles and Masses of Secretory or Ingested Material. in Eukaryotes It Includes the Nucleus and Cytoplasm. 
    5886   Plasma Membrane  The Membrane Surrounding a Cell That Separates the Cell From Its External Environment. It Consists of a Phospholipid Bilayer and Associated Proteins. 
    16021   Integral Component of Membrane  The Component of a Membrane Consisting of Gene Products and Protein Complexes That Have Some Part That Penetrates At Least One Leaflet of the Membrane Bilayer. This Component Includes Gene Products That Are Buried in the Bilayer with No Exposure Outside the Bilayer. 
    5216   Ion Channel Activity  Catalysis of Facilitated Diffusion of an Ion (by an Energy Independent Process) by Passage Through a Transmembrane Aqueous Pore or Channel Without Evidence For a Carrier Mediated Mechanism. 


     
  •   Gene Details   Hide

    Genetic Source

    Chain A,B
    Common Name Norway Rat
    Scientific Name Rattus norvegicus  
    Genus Rattus
    Gene trpv2, sac2b, vrl1
    Host Scientific Name Escherichia coli bl21(de3)  
    Host Genus Escherichia
    Host Species Escherichia Coli
    Host Strain Bl21(de3)
    Host Vector Type Plasmid
    Host Plasmid Name pET21a


    Genome Information

    Chromosome Locus Gene ID Gene Name Symbol
    10 10q23 29465     transient receptor potential cation channel, subfamily V, member 2 TRPV2