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Crystal Structure of Ephrin A2 (ephA2) Receptor Protein Kinase
Biology and Chemistry Report
1MQB
  •   Structure Details   Hide

    Structure Keywords

    Keywords TRANSFERASE
    Text Tyrosine Protein Kinase, TRANSFERASE

    Polymeric Molecules

    Chain A,B
    Description Ephrin type-A receptor 2 
    Fragment Kinase Domain 
    Nonstandard Linkage no 
    Nonstandard Monomers no 
    Polymer Type polypeptide(L) 
    Formula Weight 37783.7 
    Source Method genetically manipulated  
    Entity Name EphA2 receptor tyrosine kinase, Tyrosine-protein kinase receptor ECK, Epithelial cell kinase 

    Ligands and Prosthetic Groups

    ID Name Chemical Formula Weight Ligand Structure
    ANP  PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER  C10 H17 N6 O12 P3   506.20  View 
     
  •   Protein Details   Hide

    UniProtKB Information

    Chain SWS/UNP ID SWS/UNP Accession(s)
    A,B EPHA2_HUMAN P29317     

    Keywords and Names

    Chain(s) RCSB Name UniProtKB Name UniProtKB Keywords

    EC, Associated Pathways and Catalytic Sites

    Chain(s) IUBMB KEGG BioCyc Catalytic Site(s)
    A B  2.7.10.1        
    C: Cellular Location | F: Molecular Function | P: Biological Process
    Chain A,B
    GO ID   Ontology GO Term Definition
    6468   Protein Phosphorylation  The Process of Introducing a Phosphate Group On to a Protein. 
    4672   Protein Kinase Activity  Catalysis of the Phosphorylation of an Amino Acid Residue in a Protein Usually According to the Reaction: a Protein + ATP = a Phosphoprotein + Adp. 
    4713   Protein Tyrosine Kinase Activity  Catalysis of the Reaction: ATP + a Protein Tyrosine = Adp + Protein Tyrosine Phosphate. 
    5524   ATP Binding  Interacting Selectively and Non Covalently with ATP Adenosine 5' Triphosphate a Universally Important Coenzyme and Enzyme Regulator. 
    16772   Transferase Activity Transferring Phosphorus Containing Groups  Catalysis of the Transfer of a Phosphorus Containing Group From One Compound (donor) to Another (acceptor). 


     
  •   Gene Details   Hide

    Genetic Source

    Chain A,B
    Common Name Human
    Scientific Name Homo sapiens  
    Genus Homo
    Gene epha2
    Host Common Name Fall Armyworm
    Host Scientific Name Spodoptera frugiperda  
    Host Genus Spodoptera
    Host Cell Line Hi5
    Host Vector Type Baculovirus


    Genome Information

    Chromosome Locus Gene ID Gene Name Symbol
    1 1p36 1969     EPH receptor A2 EPHA2    

    Single Nucleotide Polymorphisms (from LS-SNP database)

    SNP ID LsSnp Link dbSNP Link Chain PDB position Amino acid changes Secondary structure Solvent Accessibility Chromosome Chromosome position Ligand
    rs34021505 LS-SNP   dbSNP   A 631 M - > T Beta Ladder 18% (Intermediate) 1 16459836
    rs144342633 LS-SNP   dbSNP   A 662 G - > S Helix 26% (Intermediate) 1 16459744
    rs145962326 LS-SNP   dbSNP   A 677 R - > H Coil 48% (Exposed) 1 16459698
    rs140398645 LS-SNP   dbSNP   A 681 V - > I Beta Ladder 5% (Buried) 1 16459687
    rs148264105 LS-SNP   dbSNP   A 697 N - > S Turn 33% (Intermediate) 1 16458898
    rs144576767 LS-SNP   dbSNP   A 702 K - > R Helix 56% (Exposed) 1 16458883
    rs150684866 LS-SNP   dbSNP   A 712 S - > G Coil 42% (Exposed) 1 16458750
    rs116506614 LS-SNP   dbSNP   A 721 R - > Q Helix 36% (Exposed) 1 16458722
    rs200893130 LS-SNP   dbSNP   A 738 R - > H Bend 52% (Exposed) 1 16458671
    rs145592908 LS-SNP   dbSNP   A 747 V - > I Beta Ladder 0% (Buried) 1 16458645
    rs55869078 LS-SNP   dbSNP   A 792 R - > W Coil 84% (Exposed) 1 16458317
    rs146970860 LS-SNP   dbSNP   A 813 Y - > N Turn 13% (Intermediate) 1 16458254
    rs200914360 LS-SNP   dbSNP   A 823 N - > S Helix 49% (Exposed) 1 16458223
    rs2291806 LS-SNP   dbSNP   A 825 E - > K Helix 48% (Exposed) 1 16458218
    rs139382402 LS-SNP   dbSNP   A 829 A - > V Helix 29% (Intermediate) 1 16456904
    rs139225059 LS-SNP   dbSNP   A 860 R - > H Turn 61% (Exposed) 1 16456811
    rs35903225 LS-SNP   dbSNP   A 876 R - > H Helix 94% (Exposed) 1 16456763