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SOLUTION STRUCTURE OF THE A-SUBUNIT OF HUMAN CHORIONIC GONADOTROPIN [MODELED WITH DIANTENNARY GLYCAN AT ASN78]
Biology and Chemistry Report
1HD4
  •   Structure Details   Hide

    Structure Keywords

    Keywords GLYCOPROTEIN
    Text HCG, GLYCOPROTEIN, CHORIONIC GONADOTROPIN, GLYCOPROTEIN STRUCTURE, XPLOR

    Polymeric Molecules

    Chain A
    Description CHORIONIC GONADOTROPIN 
    Nonstandard Linkage no 
    Nonstandard Monomers no 
    Polymer Type polypeptide(L) 
    Formula Weight 10217.8 
    Source Method natural source  

    Ligands and Prosthetic Groups

    ID Name Chemical Formula Weight Ligand Structure
    BMA  BETA-D-MANNOSE  C6 H12 O6   180.16  View 
    GAL  BETA-D-GALACTOSE  C6 H12 O6   180.16  View 
    MAN  ALPHA-D-MANNOSE  C6 H12 O6   180.16  View 
    NAG  N-ACETYL-D-GLUCOSAMINE  C8 H15 N O6   221.21  View 
     
  •   Protein Details   Hide

    UniProtKB Information

    Chain SWS/UNP ID SWS/UNP Accession(s)
    A GLHA_HUMAN P01215     

    Keywords and Names

    Chain(s) RCSB Name UniProtKB Name UniProtKB Keywords

    C: Cellular Location | F: Molecular Function | P: Biological Process
    Chain A
    GO ID   Ontology GO Term Definition
    6590   Thyroid Hormone Generation  The Formation of Either of the Compounds Secreted by the Thyroid Gland Mainly Thyroxine and Triiodothyronine. This Is Achieved by the Iodination and Joining of Tyrosine Molecules to Form the Precursor Thyroglobin Proteolysis of This Precursor Gives Rise to the Thyroid Hormones. 
    7165   Signal Transduction  The Cellular Process in Which a Signal Is Conveyed to Trigger a Change in the Activity or State of a Cell. Signal Transduction Begins with Reception of a Signal (e.g. a Ligand Binding to a Receptor or Receptor Activation by a Stimulus Such As Light) or For Signal Transduction in the Absence of Ligand Signal Withdrawal or the Activity of a Constitutively Active Receptor. Signal Transduction Ends with Regulation of a Downstream Cellular Process E.g. Regulation of Transcription or Regulation of a Metabolic Process. Signal Transduction Covers Signaling From Receptors Located On the Surface of the Cell and Signaling Via Molecules Located Within the Cell. For Signaling Between Cells Signal Transduction Is Restricted to Events At and Within the Receiving Cell. 
    7267   Cell Cell Signaling  Any Process That Mediates the Transfer of Information From One Cell to Another. 
    8284   Positive Regulation of Cell Proliferation  Any Process That Activates or Increases the Rate or Extent of Cell Proliferation. 
    8406   Gonad Development  The Process Whose Specific Outcome Is the Progression of the Gonad Over Time From Its Formation to the Mature Structure. the Gonad Is an Animal Organ That Produces Gametes; in Some Species It Also Produces Hormones. 
    16486   Peptide Hormone Processing  The Generation of a Mature Peptide Hormone by Posttranslational Processing of a Prohormone. 
    30335   Positive Regulation of Cell Migration  Any Process That Activates or Increases the Frequency Rate or Extent of Cell Migration. 
    30878   Thyroid Gland Development  The Process Whose Specific Outcome Is the Progression of the Thyroid Gland Over Time From Its Formation to the Mature Structure. the Thyroid Gland Is an Endoderm Derived Gland That Produces Thyroid Hormone. 
    32275   Luteinizing Hormone Secretion  The Regulated Release of Luteinizing Hormone a Gonadotropic Glycoprotein Hormone Secreted by the Anterior Pituitary. 
    32870   Cellular Response to Hormone Stimulus  Any Process That Results in a Change in State or Activity of a Cell (in Terms of Movement Secretion Enzyme Production Gene Expression Etc.) As a Result of a Hormone Stimulus. 
    44267   Cellular Protein Metabolic Process  The Chemical Reactions and Pathways Involving a Specific Protein Rather Than of Proteins in General Occurring At the Level of an Individual Cell. Includes Cellular Protein Modification. 
    45944   Positive Regulation of Transcription From RNA Polymerase Ii Promoter  Any Process That Activates or Increases the Frequency Rate or Extent of Transcription From an RNA Polymerase Ii Promoter. 
    46621   Negative Regulation of Organ Growth  Any Process That Stops Prevents or Reduces the Frequency Rate or Extent of Growth of an Organ of an Organism. 
    46884   Follicle Stimulating Hormone Secretion  The Regulated Release of Follicle Stimulating Hormone a Gonadotropic Glycoprotein Hormone Secreted by the Anterior Pituitary. 
    48589   Developmental Growth  The Increase in Size or Mass of an Entire Organism a Part of an Organism or a Cell Where the Increase in Size or Mass Has the Specific Outcome of the Progression of the Organism Over Time From One Condition to Another. 
    5576   Extracellular Region  The Space External to the Outermost Structure of a Cell. For Cells Without External Protective or External Encapsulating Structures This Refers to Space Outside of the Plasma Membrane. This Term Covers the Host Cell Environment Outside an Intracellular Parasite. 
    5179   Hormone Activity  The Action Characteristic of a Hormone Any Substance Formed in Very Small Amounts in One Specialized Organ or Group of Cells and Carried (sometimes in the Bloodstream) to Another Organ or Group of Cells in the Same Organism Upon Which It Has a Specific Regulatory Action. the Term Was Originally Applied to Agents with a Stimulatory Physiological Action in Vertebrate Animals (as Opposed to a Chalone Which Has a Depressant Action). Usage Is Now Extended to Regulatory Compounds in Lower Animals and Plants and to Synthetic Substances Having Comparable Effects; All Bind Receptors and Trigger Some Biological Process. 
    5515   Protein Binding  Interacting Selectively and Non Covalently with Any Protein or Protein Complex (a Complex of Two or More Proteins That May Include Other Nonprotein Molecules). 


     
  •   Gene Details   Hide

    Natural Source

    Chain A
    Common Name Human
    Scientific Name Homo sapiens  
    Details Isolated From Urine of Pregnant Woman

    Genome Information

    Chromosome Locus Gene ID Gene Name Symbol
    6 6q12-q21 1081     glycoprotein hormones, alpha polypeptide CGA    

    Single Nucleotide Polymorphisms (from LS-SNP database)

    SNP ID LsSnp Link dbSNP Link Chain PDB position Amino acid changes Secondary structure Solvent Accessibility Chromosome Chromosome position Ligand
    rs11547905 LS-SNP   dbSNP   A 13 Q - > R Coil 52% (Exposed) 6 87796131
    rs17850706 LS-SNP   dbSNP   A 17 F - > L Turn 52% (Exposed) 6 87796120
    rs11547904 LS-SNP   dbSNP   A 35 R - > G Coil 76% (Exposed) 6 87796066
    rs9986555 LS-SNP   dbSNP   A 41 L - > I Coil 117% (Exposed) 6 87796048
    rs142907318 LS-SNP   dbSNP   A 44 K - > N Bend 67% (Exposed) 6 87796037
    rs145503313 LS-SNP   dbSNP   A 53 V - > I Coil 66% (Exposed) 6 87796012
    rs202123656 LS-SNP   dbSNP   A 71 M - > T Turn 47% (Exposed) 6 87795541
    rs201187778 LS-SNP   dbSNP   A 86 T - > S Coil 68% (Exposed) 6 87795497