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SOLUTION STRUCTURE OF THE A-SUBUNIT OF HUMAN CHORIONIC GONADOTROPIN [MODELED WITH DIANTENNARY GLYCAN AT ASN78]
Biology and Chemistry Report
1HD4
  •   Structure Details   Hide

    Structure Keywords

    Keywords GLYCOPROTEIN
    Text HCG, GLYCOPROTEIN, CHORIONIC GONADOTROPIN, GLYCOPROTEIN STRUCTURE, XPLOR

    Polymeric Molecules

    Chain A
    Description CHORIONIC GONADOTROPIN 
    Nonstandard Linkage no 
    Nonstandard Monomers no 
    Polymer Type polypeptide(L) 
    Formula Weight 10217.8 
    Source Method natural source  

    Ligands and Prosthetic Groups

    ID Name Chemical Formula Weight Ligand Structure
    BMA  BETA-D-MANNOSE  C6 H12 O6   180.16  View 
    GAL  BETA-D-GALACTOSE  C6 H12 O6   180.16  View 
    MAN  ALPHA-D-MANNOSE  C6 H12 O6   180.16  View 
    NAG  N-ACETYL-D-GLUCOSAMINE  C8 H15 N O6   221.21  View 
     
  •   Protein Details   Hide

    UniProtKB Information

    Chain SWS/UNP ID SWS/UNP Accession(s)
    A GLHA_HUMAN P01215     

    Keywords and Names

    Chain(s) RCSB Name UniProtKB Name UniProtKB Keywords

    C: Cellular Location | F: Molecular Function | P: Biological Process
    Chain A
    GO ID   Ontology GO Term Definition
    5576   Extracellular Region  The Space External to the Outermost Structure of a Cell. For Cells Without External Protective or External Encapsulating Structures This Refers to Space Outside of the Plasma Membrane. This Term Covers the Host Cell Environment Outside an Intracellular Parasite. 
    5179   Hormone Activity  The Action Characteristic of a Hormone Any Substance Formed in Very Small Amounts in One Specialized Organ or Group of Cells and Carried (sometimes in the Bloodstream) to Another Organ or Group of Cells in the Same Organism Upon Which It Has a Specific Regulatory Action. the Term Was Originally Applied to Agents with a Stimulatory Physiological Action in Vertebrate Animals (as Opposed to a Chalone Which Has a Depressant Action). Usage Is Now Extended to Regulatory Compounds in Lower Animals and Plants and to Synthetic Substances Having Comparable Effects; All Bind Receptors and Trigger Some Biological Process. 
    5515   Protein Binding  Interacting Selectively and Non Covalently with Any Protein or Protein Complex (a Complex of Two or More Proteins That May Include Other Nonprotein Molecules). 


     
  •   Gene Details   Hide

    Natural Source

    Chain A
    Common Name Human
    Scientific Name Homo sapiens  
    Details Isolated From Urine of Pregnant Woman

    Genome Information

    Chromosome Locus Gene ID Gene Name Symbol
    6 6q12-q21 1081     glycoprotein hormones, alpha polypeptide CGA    

    Single Nucleotide Polymorphisms (from LS-SNP database)

    SNP ID LsSnp Link dbSNP Link Chain PDB position Amino acid changes Secondary structure Solvent Accessibility Chromosome Chromosome position Ligand
    rs11547905 LS-SNP   dbSNP   A 13 Q - > R Coil 52% (Exposed) 6 87796131
    rs17850706 LS-SNP   dbSNP   A 17 F - > L Turn 52% (Exposed) 6 87796120
    rs11547904 LS-SNP   dbSNP   A 35 R - > G Coil 76% (Exposed) 6 87796066
    rs9986555 LS-SNP   dbSNP   A 41 L - > I Coil 117% (Exposed) 6 87796048
    rs142907318 LS-SNP   dbSNP   A 44 K - > N Bend 67% (Exposed) 6 87796037
    rs145503313 LS-SNP   dbSNP   A 53 V - > I Coil 66% (Exposed) 6 87796012
    rs202123656 LS-SNP   dbSNP   A 71 M - > T Turn 47% (Exposed) 6 87795541
    rs201187778 LS-SNP   dbSNP   A 86 T - > S Coil 68% (Exposed) 6 87795497