POP-OUT | CLOSE
 
3-ISOPROPYLMALATE DEHYDROGENASE (IPMDH) FROM SALMONELLA TYPHIMURIUM
Biology and Chemistry Report
1CNZ
  •   Structure Details   Hide

    Structure Keywords

    Keywords OXIDOREDUCTASE
    Text OXIDOREDUCTASE, DEHYDROGENASE, LEUCINE BIOSYNTHETIC PATHWAY, NAD-DEPENDANT ENZYME

    Polymeric Molecules

    Chain A,B
    Description PROTEIN (3-ISOPROPYLMALATE DEHYDROGENASE) 
    Nonstandard Linkage no 
    Nonstandard Monomers no 
    Polymer Type polypeptide(L) 
    Formula Weight 39557.3 
    Source Method genetically manipulated  
    Entity Name IPMDH, IMDH 

    Ligands and Prosthetic Groups

    ID Name Chemical Formula Weight Ligand Structure
    MN  MANGANESE (II) ION  Mn   54.94  View 
    SO4  SULFATE ION  O4 S   96.06  View 
     
  •   Protein Details   Hide

    UniProtKB Information

    Chain SWS/UNP ID SWS/UNP Accession(s)
    A,B LEU3_SALTY P37412     

    Keywords and Names

    Chain(s) RCSB Name UniProtKB Name UniProtKB Keywords

    EC, Associated Pathways and Catalytic Sites

    Chain(s) IUBMB KEGG BioCyc Catalytic Site(s)
    A B  1.1.1.85        
    C: Cellular Location | F: Molecular Function | P: Biological Process
    Chain A,B
    GO ID   Ontology GO Term Definition
    8652   Cellular Amino Acid Biosynthetic Process  The Chemical Reactions and Pathways Resulting in the Formation of Amino Acids Organic Acids Containing One or More Amino Substituents. 
    9082   Branched Chain Amino Acid Biosynthetic Process  The Chemical Reactions and Pathways Resulting in the Formation of Amino Acids Containing a Branched Carbon Skeleton Comprising Isoleucine Leucine and Valine. 
    9098   Leucine Biosynthetic Process  The Chemical Reactions and Pathways Resulting in the Formation of Leucine 2 Amino 4 Methylpentanoic Acid. 
    55114   Oxidation Reduction Process  A Metabolic Process That Results in the Removal or Addition of One or More Electrons to or From a Substance with or Without the Concomitant Removal or Addition of a Proton or Protons. 
    5737   Cytoplasm  All of the Contents of a Cell Excluding the Plasma Membrane and Nucleus But Including Other Subcellular Structures. 
    287   Magnesium Ion Binding  Interacting Selectively and Non Covalently with Magnesium (mg) Ions. 
    3862   3 Isopropylmalate Dehydrogenase Activity  Catalysis of the Reaction: 3 Carboxy 2 Hydroxy 4 Methylpentanoate + Nad+ = 3 Carboxy 4 Methyl 2 Oxopentanoate + Nadh + H+. 
    16491   Oxidoreductase Activity  Catalysis of an Oxidation Reduction (redox) Reaction a Reversible Chemical Reaction in Which the Oxidation State of an Atom or Atoms Within a Molecule Is Altered. One Substrate Acts As a Hydrogen or Electron Donor and Becomes Oxidized While the Other Acts As Hydrogen or Electron Acceptor and Becomes Reduced. 
    16616   Oxidoreductase Activity Acting On the Ch Oh Group of Donors NAD or Nadp As Acceptor  Catalysis of an Oxidation Reduction (redox) Reaction in Which a Ch Oh Group Acts As a Hydrogen or Electron Donor and Reduces Nad+ or Nadp. 
    46872   Metal Ion Binding  Interacting Selectively and Non Covalently with Any Metal Ion. 
    51287   NAD Binding  Interacting Selectively and Non Covalently with Nicotinamide Adenine Dinucleotide a Coenzyme Involved in Many Redox and Biosynthetic Reactions; Binding May Be to Either the Oxidized Form Nad+ or the Reduced Form Nadh. 


     
  •   Gene Details   Hide

    Genetic Source

    Chain A,B
    Scientific Name Salmonella typhimurium  
    Genus Salmonella
    Gene leu b
    Host Scientific Name Escherichia coli  
    Host Genus Escherichia


    Genome Information

    Chromosome Locus Gene ID Gene Name Symbol
    - - 1251630     3-isopropylmalate dehydrogenase LEUB