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Crystal structure of human liver delta(4)-3-ketosteroid 5beta-reductase (akr1d1) in complex with progesterone and nadp. Resolution: 2.03 A.
3COT
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Oxidoreductase
    Structure Weight: 81314.96
    Molecule: 3-oxo-5-beta-steroid 4-dehydrogenase
    Polymer: 1 Type: protein Length: 346
    Chains: A, B
    EC#: 1.3.1.3   
    Organism: Homo sapiens
    Gene Names: Gene View for AKR1D1 SRD5B1
    UniProtKB: Protein Feature View | Search PDB | P51857  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    3CMF  THE SAME PROTEIN IN COMPLEX WITH CORTISOEN AND NADP 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    NAP
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    NAP C21 H28 N7 O17 P3
    NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
    STR
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    STR C21 H30 O2
    PROGESTERONE
    STR:3COT
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly 1       
Biological assembly 1 assigned by authors and generated by PISA (software)
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