Crystal structure of human Delta(4)-3-ketosteroid 5-beta-reductase in complex with NADP and HEPES. Resolution: 1.35 A.     DOI:10.2210/pdb3buv/pdb

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Primary Citation       Molecular Description Hide Classification: Oxidoreductase Structure Weight: 76765.71   Molecule: 3-oxo-5-beta-steroid 4-dehydrogenase Polymer: 1 Type: polypeptide(L) Length: 326 Chains: A, B EC#: 1.3.1.3          Source Hide Polymer: 1 Scientific Name: Homo sapiens Common Name: Human Expression System: Escherichia coli         Related PDB Entries Hide Id Details 3BUR  Same enzyme in complex with NADP and TESTOSTERONE        Ligand Chemical Component Hide Identifier Name Formula Interaction View Links EPE     4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID C8 H18 N2 O4 S Ligand Explorer GOL     GLYCEROL C3 H8 O3 Ligand Explorer NAP     NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE C21 H28 N7 O17 P3 Ligand Explorer       Derived Data Hide CATH Classification v3.2.0 - (2 Domains) PFAM Classification - (2 Domains) GO Terms - (16 Terms)     Reset Layout

Biological Assembly 1     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly 1 assigned by authors and generated by PISA (software) Biological assembly 2 assigned by authors and generated by PISA (software)         Deposition Summary Hide Authors:   Di Costanzo, L.,   Drury, J.,   Penning, T.M.,   Christianson, D.W. Deposition:   2008-01-03 Release:   2008-04-01 Last Modified (REVDAT):   2009-02-24       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:    [ EDS ] Resolution[Å]: 1.35 R-Value: 0.218 (obs.) R-Free: 0.232 Space Group: P 21 21 21 Unit Cell:   Length [Å] Angles [°] a = 49.71 α = 90.00  b = 109.80 β = 90.00  c = 128.02 γ = 90.00