Crystal structure of porcine heart mitochondrial complex II bound with N-(3-Dimethylaminomethyl-phenyl)-2-trifluoromethyl-benzamide DOI:10.2210/pdb3aea/pdb

3AEA   Display Files  close FASTA Sequence PDB File PDB File (Header) mmCIF File mmCIF File (Header) PDBML/XML File PDBML/XML File (Header)   Download Files  close FASTA Sequence PDB File (Text) PDB File (gz) mmCIF File mmCIF File (gz) PDBML/XML File PDBML/XML File (gz) Structure Factor (Text) Structure Factor (gz) Biological Assembly (gz) (A+S)   Share this Page  close Facebook Twitter LinkedIn Email Link this Page

Primary Citation       Related Citations in PDB Entry (REMARK 1) Hide     Molecular Description Hide Classification: Oxidoreductase/oxidoreductase Inhibitor Structure Weight: 126678.79 Molecule: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Polymer: 1 Type: protein Length: 622 Chains: A EC#: 1.3.5.1    Organism Sus scrofa Gene Name SDHA UniProtKB:   Protein Feature View | Search PDB | Q0QF01     Molecule: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Polymer: 2 Type: protein Length: 252 Chains: B EC#: 1.3.5.1    Organism Sus scrofa Gene Name SDHB UniProtKB:   Protein Feature View | Search PDB | Q007T0     Molecule: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Polymer: 3 Type: protein Length: 140 Chains: C Organism Sus scrofa Gene Name SDHC UniProtKB:   Protein Feature View | Search PDB | D0VWV4     Molecule: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Polymer: 4 Type: protein Length: 103 Chains: D Fragment: residues 57-159 Organism Sus scrofa Gene Name SDHD UniProtKB:   Protein Feature View | Search PDB | A5GZW8         Source Hide Polymer: 1 Scientific Name: Sus scrofa   Taxonomy   Common Name: Pig   Polymer: 2 Scientific Name: Sus scrofa   Taxonomy   Common Name: Pig   Polymer: 3 Scientific Name: Sus scrofa   Taxonomy   Common Name: Pig   Polymer: 4 Scientific Name: Sus scrofa   Taxonomy   Common Name: Pig       Related PDB Entries Hide Identifier Details 3ABV  the same protein complex bound with another inhibitor  3AE1  the same protein complex bound with another inhibitor  3AE2  the same protein complex bound with another inhibitor  3AE3  the same protein complex bound with another inhibitor  3AE4  the same protein complex bound with another inhibitor  3AE5  the same protein complex bound with another inhibitor  3AE6  the same protein complex bound with another inhibitor  3AE7  the same protein complex bound with another inhibitor  3AE8  the same protein complex bound with another inhibitor  3AE9  the same protein complex bound with another inhibitor  3AEB  the same protein complex bound with another inhibitor  3AEC  the same protein complex bound with another inhibitor  3AED  the same protein complex bound with another inhibitor  3AEE  the same protein complex bound with another inhibitor  3AEF  the same protein complex with an empty quinone-binding pocket  3AEG  the same protein complex bound with another inhibitor      Ligand Chemical Component Hide Identifier Formula Name Interactions EPH Search  Download  C39 H68 N O8 P L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL- PHOSPHATIDYLETHANOLAMINE   Ligand Explorer F3S Search  Download  Fe3 S4 FE3-S4 CLUSTER   Ligand Explorer F9A Search  Download  C17 H17 F3 N2 O N-{3-[(dimethylamino)methyl]phenyl}-2-(trifluoromethyl)benzamide   Ligand Explorer FAD Search  Download  C27 H33 N9 O15 P2 FLAVIN-ADENINE DINUCLEOTIDE   Ligand Explorer FES Search  Download  Fe2 S2 FE2/S2 (INORGANIC) CLUSTER   Ligand Explorer HEM Search  Download  C34 H32 Fe N4 O4 PROTOPORPHYRIN IX CONTAINING FE   Ligand Explorer MLI Search  Download  C3 H2 O4 MALONATE ION   Ligand Explorer SF4 Search  Download  Fe4 S4 IRON/SULFUR CLUSTER   Ligand Explorer     External Domain Annotations Hide Pfam Classification: 8 Domains - data from Pfam   GO Terms: 26 Terms - data from GO      Structural Biology Knowledgebase Data Hide     Data in orange boxes are gathered from external resources (when available). Reset Layout

Biological Assembly            View in 3D More Images... Biological assembly 1 assigned by authors and generated by PISA (software) Downloadable viewers: Simple Viewer Protein Workshop Ligand Explorer Kiosk Viewer Other Viewers  KiNG WebMol QuickPDB FirstGlance         MyPDB Personal Annotations Hide     Deposition Summary Hide Authors:   Harada, S.,  Sasaki, T.,  Shindo, M.,  Kido, Y.,  Inaoka, D.K.,  Omori, J.,  Osanai, A.,  Sakamoto, K.,  Mao, J.,  Matsuoka, S.,  Inoue, M.,  Honma, T.,  Tanaka, A.,  Kita, K. Deposition:   2010-02-04 Release:   2011-02-09     Revision History    Hide Mouse over text for details 2011-07-13 Version format compliance     Experimental Details Hide Method:   X-RAY DIFFRACTION Exp. Data:   Structure Factors EDS   Resolution[Å]:   3.39 R-Value: 0.239 (obs.) R-Free: 0.286 Space Group: P 21 21 21 Unit Cell:   Length [Å] Angles [°] a = 71.50 α = 90.00  b = 83.75 β = 90.00  c = 294.96 γ = 90.00      Molecule of the Month Hide Citric Acid Cycle