THE CRYSTAL STRUCTURE OF PPIL1 IN COMPLEX WITH CYCLOSPORINE A SUGGESTS A BINDING MODE FOR SKIP DOI:10.2210/pdb2x7k/pdb

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Primary Citation       Related Citations in PDB Entry (REMARK 1) Hide     Molecular Description Hide Classification: Isomerase/immunosuppressant Structure Weight: 19726.35 Molecule: PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 1 Polymer: 1 Type: protein Length: 166 Chains: A EC#: 5.2.1.8    Organism Homo sapiens Gene Names PPIL1 CYPL1 CGI-124 UNQ2425/PRO4984 UniProtKB:   Protein Feature View | Search PDB | Q9Y3C6     Molecule: CYCLOSPORIN A Polymer: 2 Type: protein Length: 11 Chains: B Organism Tolypocladium inflatum     Source Hide Polymer: 1 Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli   Polymer: 2 Scientific Name: Synthetic construct (Tolypocladium inflatum)   Taxonomy         Related PDB Entries Hide Identifier Details 1BCK  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH CYCLOSPORIN C  1C5F  CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A  1CSA  SOLUTION STRUCTURE OF E.COLI CYCLOPHILIN (F112W) COMPLEXED WITH CYCLOSPORIN A  1CWA  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH CYCLOSPORIN A  1CWB  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN A AT POSITION 5  1CWC  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN A AT POSITION 8  1CWF  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH CYCLOSPORIN D  1CWH  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH CYCLOSPORIN A MODIFIED AT POSITION 7  1CWI  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN D AT POSITION 7  1CWJ  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN D AT POSITIONS 5 AND 7.  1CWK  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN D AT POSITIONS 5 AND 7.  1CWL  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN A AT POSITION 8  1CWM  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN A AT POSITION 8  1CWO  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH NODIFIED CYCLOSPORIN C AT POSITIONS 1, AND 9  1CYA  SOLUTION STRUCTURE OF HUMAN CYCLOPHILIN COMPLEXED WIYH CYCLOSPORIN A  1CYB  SOLUTION STRUCTURE OF HUMAN CYCLOPHILIN COMPLEXED WITH CYCLOSPORIN A  1CYN  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN B COMPLEXED WITH MODIFIED CYCLOSPORIN A  1IKF  CRYSTAL STRUCTURE OF CTCLOSPORIN-FAB COMPLEX  1M63  CRYSTAL STRUCTURE OF CALCINEURIN-CYCLOPHILIN-CYCLOSPORIN COMPLEX  1MF8  CRYSTAL STRUCTURE OF HUMAN CALCINEURIN COMPLEXED WITH HUMAN CYCLOPHILIN AND CYCLOSPORIN A  1MIK  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN A AT POSITION 6  1QNG  CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM CYCLOPHILIN COMPLEXED WITH CYCLOSPORIN A  1QNH  CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM CYCLOPHILIN (DOUBLE MUTANT) COMPLEXED WITH CYCLOSPORIN A  1XQ7  CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI CYCLOPHILIN COMPLEXED WITH CYCLOSPORIN A  1XWN  SOLUTION STRUCTURE OF CYCLOPHILIN LIKE 1(PPIL1) AND INSIGHTS INTO ITS INTERACTION WITH SKIP  2ESL  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN C COMPLEXED WITH CYCLOSPORIN A  2OJU  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN J COMPLEXED WITH CYCLOSPORIN A  2POY  CRYSTAL STRUCTURE OF CRYPTOSPORIDIUM PARVUM IOWA II CYCLOPHILIN A COMPLEXED WITH CYCLOSPORIN A  2RMA  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH CYCLOSPORIN A  2RMB  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN A AT POSITION 5  2RMC  CRYSTAL STRUCTURE OF MURINE CYCLOPHILIN C COMPLEXED WITH CYCLOSPORIN A  2WFJ  CRYSTAL STRUCTURE OF THE PPIASE DOMAIN OF HUMAN CYCLOPHILIN G COMPLEXED WITH CYCLOSPORIN A  2X2C  CRYSTAL STRUCTURE OF HUMAN ACETYL-CYPA COMPLEXED WITH CYCLOSPORINE A  2Z6W  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN D IN COMPLEX WITH CYCLOSPORIN A  3BO7  CRYSTAL STRUCTURE OF CYCLOSPHILIN A FROM TOXOPLASMA GONDII COMPLEXED WIT CYCLOSPORIN A  3CYS  SOLUTION STRUCTURE OF THE HUMAN CYCLOSPORIN A COMPLEXED WITH CYCLOSPORIN A  3EOV  CRYSTAL STRUCTURE OF CYCLOPHILIN FROM LEISHMANIA DONOVANI COMPLEXED WITH CYCLOSPORIN A      Biologically Interesting Molecules (BIRD) Hide Identifier Image Name Type Class Chain ID   PRD_000142 Search  Cyclosporin A Cyclic peptide Immunosuppressant B   Ligand Explorer     Ligand Chemical Component Hide Identifier Formula Name Interactions CD Search  Download  Cd CADMIUM ION   Ligand Explorer NA Search  Download  Na SODIUM ION   Ligand Explorer     Modified Residues Hide Identifier Formula Parent Type DAL Search  C3 H7 N O2 dPeptideLinking MLE Search  C7 H15 N O2 LEU lPeptideLinking MVA Search  C6 H13 N O2 VAL lPeptideLinking BMT Search  C10 H19 N O3 THR lPeptideLinking ABA Search  C4 H9 N O2 ALA lPeptideLinking SAR Search  C3 H7 N O2 GLY glycine     External Domain Annotations Hide Pfam Classification: 1 Domain - data from Pfam   GO Terms: 10 Terms - data from GO      Structural Biology Knowledgebase Data Hide     Data in orange boxes are gathered from external resources (when available). 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Biological Assembly            View in 3D More Images... Biological assembly 1 assigned by authors and generated by PISA (software) Downloadable viewers: Simple Viewer Protein Workshop Ligand Explorer Kiosk Viewer Other Viewers  KiNG WebMol QuickPDB FirstGlance         MyPDB Personal Annotations Hide     Deposition Summary Hide Authors:   Stegmann, C.M.,  Luehrmann, R.,  Wahl, M.C. Deposition:   2010-03-01 Release:   2010-03-23 Last Modified (REVDAT):   2011-07-13     Revision History    Hide Mouse over text for details 2012-12-12 Other 2011-07-13 Polymer description 2011-07-13 Version format compliance 2011-07-13 Linkage 2011-07-13 Sequence database correspondence 2011-07-13 Function and keywords 2011-07-13 Atom nomenclature 2011-07-13 Binding sites and description     Experimental Details Hide Method:   X-RAY DIFFRACTION Exp. Data:   Structure Factors EDS   Resolution[Å]:   1.15 R-Value: 0.129 (obs.) R-Free: 0.149 Space Group: P 21 21 2 Unit Cell:   Length [Å] Angles [°] a = 103.22 α = 90.00  b = 35.70 β = 90.00  c = 45.85 γ = 90.00