Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in complex with cyclosporin A. DOI:10.2210/pdb2wfj/pdb

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Primary Citation       Related Citations in PDB Entry (REMARK 1) Hide     Molecular Description Hide Classification: Isomerase/immunosuppressant Structure Weight: 21210.37 Molecule: PEPTIDYL-PROLYL CIS-TRANS ISOMERASE G Polymer: 1 Type: protein Length: 179 Chains: A EC#: 5.2.1.8    Fragment: PPIASE DOMAIN, RESIDUES 1-177 Organism Homo sapiens Gene Name PPIG UniProtKB:   Protein Feature View | Search PDB | Q13427     Molecule: CYCLOSPORIN A Polymer: 2 Type: protein Length: 11 Chains: B Organism Tolypocladium inflatum     Source Hide Polymer: 1 Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli   Polymer: 2 Scientific Name: Synthetic construct (Tolypocladium inflatum)   Taxonomy         Related PDB Entries Hide Identifier Details 1BCK  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH CYCLOSPORIN C  1C5F  CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A  1CSA  SOLUTION STRUCTURE OF E.COLI CYCLOPHILIN (F112W) COMPLEXED WITH CYCLOSPORIN A  1CWA  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH CYCLOSPORIN A  1CWB  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN A AT POSITION 5  1CWC  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN A AT POSITION 8  1CWF  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH CYCLOSPORIN D  1CWH  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH CYCLOSPORIN A MODIFIED AT POSITION 7  1CWI  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN D AT POSITION 7  1CWJ  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN D AT POSITIONS 5 AND 7.  1CWK  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN D AT POSITIONS 5 AND 7.  1CWL  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN A AT POSITION 8  1CWM  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN A AT POSITION 8  1CWO  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH NODIFIED CYCLOSPORIN C AT POSITIONS 1, AND 9  1CYA  SOLUTION STRUCTURE OF HUMAN CYCLOPHILIN COMPLEXED WIYH CYCLOSPORIN A  1CYB  SOLUTION STRUCTURE OF HUMAN CYCLOPHILIN COMPLEXED WITH CYCLOSPORIN A  1CYN  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN B COMPLEXED WITH MODIFIED CYCLOSPORIN A  1IKF  CRYSTAL STRUCTURE OF CTCLOSPORIN-FAB COMPLEX  1M63  CRYSTAL STRUCTURE OF CALCINEURIN-CYCLOPHILIN-CYCLOSPORIN COMPLEX  1MF8  CRYSTAL STRUCTURE OF HUMAN CALCINEURIN COMPLEXED WITH HUMAN CYCLOPHILIN AND CYCLOSPORIN A  1MIK  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN A AT POSITION 6  1QNG  CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM CYCLOPHILIN COMPLEXED WITH CYCLOSPORIN A  1QNH  CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM CYCLOPHILIN (DOUBLE MUTANT) COMPLEXED WITH CYCLOSPORIN A  1XQ7  CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI CYCLOPHILIN COMPLEXED WITH CYCLOSPORIN A  2ESL  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN C COMPLEXED WITH CYCLOSPORIN A  2GW2  CRYSTAL STRUCTURE OF THE PEPTIDYL-PROLYL ISOMERASE DOMAINOF HUMAN CYCLOPHILIN G  2OJU  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN J COMPLEXED WITH CYCLOSPORIN A  2POY  CRYSTAL STRUCTURE OF CRYPTOSPORIDIUM PARVUM IOWA II CYCLOPHILIN A COMPLEXED WITH CYCLOSPORIN A  2RMA  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH CYCLOSPORIN A  2RMB  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN A COMPLEXED WITH MODIFIED CYCLOSPORIN A AT POSITION 5  2RMC  CRYSTAL STRUCTURE OF MURINE CYCLOPHILIN C COMPLEXED WITH CYCLOSPORIN A  2WFI  ATOMIC RESOLUTION CRYSTAL STRUCTURE OF THE PPIASE DOMAIN OF HUMAN CYCLOPHILIN G  2X2C  CRYSTAL STRUCTURE OF HUMAN ACETYL-CYPA COMPLEXED WITH CYCLOSPORINE A  2X7K  CRYSTAL STRUCTURE OF PPIL1 COMPLEXED WITH CYCLOSPORINE A  2Z6W  CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN D IN COMPLEX WITH CYCLOSPORIN A  3BO7  CRYSTAL STRUCTURE OF CYCLOSPHILIN A FROM TOXOPLASMA GONDII COMPLEXED WIT CYCLOSPORIN A  3CYS  SOLUTION STRUCTURE OF THE HUMAN CYCLOSPORIN A COMPLEXED WITH CYCLOSPORIN A  3EOV  CRYSTAL STRUCTURE OF CYCLOPHILIN FROM LEISHMANIA DONOVANI COMPLEXED WITH CYCLOSPORIN A      Biologically Interesting Molecules (BIRD) Hide Identifier Image Name Type Class Chain ID   PRD_000142 Search  Cyclosporin A Cyclic peptide Immunosuppressant B   Ligand Explorer     Ligand Chemical Component Hide Identifier Formula Name Interactions CL Search  Download  Cl CHLORIDE ION   Ligand Explorer EDO Search  Download  C2 H6 O2 1,2-ETHANEDIOL   Ligand Explorer MG Search  Download  Mg MAGNESIUM ION   Ligand Explorer     Modified Residues Hide Identifier Formula Parent Type DAL Search  C3 H7 N O2 dPeptideLinking MLE Search  C7 H15 N O2 LEU lPeptideLinking MVA Search  C6 H13 N O2 VAL lPeptideLinking BMT Search  C10 H19 N O3 THR lPeptideLinking ABA Search  C4 H9 N O2 ALA lPeptideLinking SAR Search  C3 H7 N O2 GLY glycine     External Domain Annotations Hide Pfam Classification: 1 Domain - 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Biological Assembly            View in 3D More Images... Biological assembly 1 assigned by authors and generated by PQS (software) Downloadable viewers: Simple Viewer Protein Workshop Ligand Explorer Kiosk Viewer Other Viewers  KiNG WebMol QuickPDB FirstGlance         MyPDB Personal Annotations Hide     Deposition Summary Hide Authors:   Stegmann, C.M.,  Sheldrick, G.M.,  Wahl, M.C. Deposition:   2009-04-06 Release:   2009-06-16 Last Modified (REVDAT):   2011-11-23     Revision History    Hide Mouse over text for details 2012-12-12 Other 2011-11-23 Citation 2011-07-13 Linkage 2011-07-13 Sequence database correspondence 2011-07-13 Function and keywords 2011-07-13 Atom nomenclature 2011-07-13 Binding sites and description 2011-07-13 Polymer description 2011-07-13 Version format compliance     Experimental Details Hide Method:   X-RAY DIFFRACTION Exp. Data:   Structure Factors Resolution[Å]:   0.75 R-Value: 0.111 (obs.) R-Free: 0.129 Space Group: P 21 21 21 Unit Cell:   Length [Å] Angles [°] a = 37.32 α = 90.00  b = 64.91 β = 90.00  c = 69.29 γ = 90.00