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X-ray crystal structure of human Mcl-1 in complex with Bim BH3
2PQK
Primary Citation
 
 
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  •   Molecular Description Hide
    Classification: Apoptosis
    Structure Weight: 21542.43
    Molecule: Induced myeloid leukemia cell differentiation protein Mcl-1
    Polymer: 1 Type: protein Length: 158
    Chains: A
    Fragment: residues 172-327
    Organism Homo sapiens
    Gene Names MCL1 BCL2L3
    UniProtKB:   Protein Feature View | Search PDB | Q07820  
    Molecule: Bim BH3 peptide
    Polymer: 2 Type: protein Length: 29
    Chains: B
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Synthetic construct   Taxonomy    
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name Interactions
    NA
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    Download      		NA Na
    SODIUM ION
    ZN
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    Download      		ZN Zn
    ZINC ION
     
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Data in orange boxes are gathered from external resources (when available).
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  Biological Assembly 1       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Bare, E.,  Grant, R.A.,  Keating, A.E.

    Deposition:   2007-05-02
    Release:   2007-06-19
    Last Modified (REVDAT):   2013-04-10
     
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    2013-04-10
    Citation
    2011-07-13
    Flag residual B-value
    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   2.00
    R-Value: 0.196 (obs.)
    R-Free: 0.229
    Space Group: I 2 2 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 53.09 α = 90.00 
    b = 71.85 β = 90.00 
    c = 118.14 γ = 90.00