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CRYSTAL STRUCTURE OF PHOSPHORYLATED RET TYROSINE KINASE DOMAIN
2IVT
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 36227.78
    Molecule: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR
    Polymer: 1 Type: protein Length: 314
    Chains: A
    EC#: 2.7.10.1   
    Fragment: TYROSINE KINASE DOMAIN, RESIDUES 705-1013
    Details: PTR AT 905
    Organism Homo sapiens
    Gene Names RET CDHF12 CDHR16 PTC RET51
    UniProtKB:   Protein Feature View | Search PDB | P07949  
     
  •   Structure Validation Hide

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  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Spodoptera frugiperda  
     
  •   Related PDB Entries Hide
    Identifier Details
    1XPD  THEORETICAL MODEL OF RET_HUMAN 
    2IVS  CRYSTAL STRUCTURE OF NON-PHOSPHORYLATED RET TYROSINE KINASE DOMAIN 
    2IVU  CRYSTAL STRUCTURE OF PHOSPHORYLATED RET TYROSINE KINASE DOMAIN COMPLEXED WITH THE INHIBITOR ZD6474 
    2IVV  CRYSTAL STRUCTURE OF PHOSPHORYLATED RET TYROSINE KINASE DOMAIN COMPLEXED WITH THE INHIBITOR PP1 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    AMP
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    AMP C10 H14 N5 O7 P
    ADENOSINE MONOPHOSPHATE
    AMP:2IVT
    FMT
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    FMT C H2 O2
    FORMIC ACID
     
  •   Modified Residues Hide
    Identifier Formula Parent Type
    PTR
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    PTR C9 H12 N O6 P TYR lPeptideLinking
     
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  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PQS (software)
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  •   Deposition Summary Hide
    Authors:   Knowles, P.P.,  Murray-Rust, J.,  Mcdonald, N.Q.

    Deposition:   2006-06-16
    Release:   2006-08-14
    Last Modified (REVDAT):   2009-02-24
     
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
    N/A
    Resolution[Å]:   2.60
    R-Value: 0.187 (obs.)
    R-Free: 0.249
    Space Group: C 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 72.13 α = 90.00 
    b = 70.85 β = 101.13 
    c = 78.92 γ = 90.00