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Co-crystal structure of znf ubp domain from the deubiquitinating enzyme isopeptidase T (isot) in complex with ubiquitin
2G45
Primary Citation
 
 
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  •   Molecular Description Hide
    Classification: Hydrolase
    Structure Weight: 46507.03
    Molecule: Ubiquitin carboxyl-terminal hydrolase 5
    Polymer: 1 Type: protein Length: 129
    Chains: A, D
    EC#: 3.4.19.12   
    Fragment: The ZnF UBP domain of IsoT (residues 163-291)
    Organism Homo sapiens
    Gene Names USP5 ISOT
    UniProtKB:   Protein Feature View | Search PDB | P45974  
    Molecule: Ubiquitin
    Polymer: 2 Type: protein Length: 76
    Chains: B, E
    Organism Homo sapiens
    Gene Name UBC
    UniProtKB:   Protein Feature View | Search PDB | P0CG48  
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
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    Identifier Details
    2G43  Structure of IsoT ZnF domain 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name Interactions
    CL
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    Download      		CL Cl
    CHLORIDE ION
    ZN
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    Download      		ZN Zn
    ZINC ION
     
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Data in orange boxes are gathered from external resources (when available).
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  Biological Assembly 1       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Reyes-Turcu, F.E.,  Horton, J.R.,  Mullally, J.E.,  Heroux, A.,  Cheng, X.,  Wilkinson, K.D.

    Deposition:   2006-02-21
    Release:   2006-04-04
    Last Modified (REVDAT):   2009-02-24
     
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
    N/A
    Resolution[Å]:   1.99
    R-Value: 0.229 (obs.)
    R-Free: 0.268
    Space Group: P 64
    Unit Cell:
      Length [Å] Angles [°]
    a = 68.07 α = 90.00 
    b = 68.07 β = 90.00 
    c = 225.35 γ = 120.00