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LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 3-(1,3,7-TRIHYDRO-9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL) 1,1 DIFLUOROPENTANE-1-PHOSPHATE
2C94
Primary Citation
 
 
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  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 85044.86
    Molecule: 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE
    Polymer: 1 Type: protein Length: 160
    Chains: A, B, C, D, E
    EC#: 2.5.1.78   
    Organism Mycobacterium tuberculosis
    Gene Names ribH Rv1416 MT1459 MTCY21B4.34
    UniProtKB:   Protein Feature View | Search PDB | P66034  
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Mycobacterium tuberculosis   Taxonomy   Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    1W19  LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 3-(1,3,7-TRIHYDRO- 9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL) PROPANE 1-PHOSPHATE 
    1W29  LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 3-(1,3,7-TRIHYDRO- 9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL) BUTANE 1-PHOSPHATE 
    2C92  LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 3-(1,3,7-TRIHYDRO- 9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL) PENTANE 1 PHOSPHATE 
    2C97  LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 4-(6-CHLORO-2,4- DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL) BUTYL PHOSPHATE 
    2C9B  LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 3-(1,3,7-TRIHYDRO- 9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL) 
    2C9D  LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 3-(1,3,7-TRIHYDRO- 9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL) HEXANE 1-PHOSPHATE 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name Interactions
    K
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    POTASSIUM ION
    TSF
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    Download      		TSF C15 H23 F2 N4 O10 P
    3-(1,3,7-TRIHYDRO-9-D-RIBITYL-2,6,8-PURINETRIONE- 7-YL) 1,1 DIFLUOROPENTANE-1-PHOSPHATE
    		TSF:2C94
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    TSF
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    N/Ain BindingDB
    Ka: 6.54e+06 M-1 - data from BindingMOAD  
    Kd: 150 nM - data from PDBbind  
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
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  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PQS (software)
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