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Crystal structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles
1YC4
Primary Citation
 
 
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  •   Molecular Description Hide
    Classification: Cell Cycle
    Structure Weight: 30080.79
    Molecule: Heat shock protein HSP 90-alpha
    Polymer: 1 Type: protein Length: 264
    Chains: A
    Fragment: sequence database residues 8-223
    Mutation: M12C
    Organism Homo sapiens
    Gene Names HSP90AA1 HSP90A HSPC1 HSPCA
    UniProtKB:   Protein Feature View | Search PDB | P07900  
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli bl21  
     
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    Identifier Details
    1yc1   
    1yc3   
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name Interactions
    43P
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    Download      		43P C14 H14 N4 O2
    4-(1H-IMIDAZOL-4-YL)-3-(5-ETHYL-2,4-DIHYDROXY- PHENYL)-1H-PYRAZOLE
    		43P:1YC4
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    43P
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    Download      		43P
    Kd: 280 nM (91) - data from BindingDB  
    Kd: 280 nM - data from BindingMOAD  
    Kd: 280 nM - data from PDBbind  
     
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Data in orange boxes are gathered from external resources (when available).
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