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Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
1X2R
Primary Citation
 
 
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  •   Molecular Description Hide
    Classification: Transcription
    Structure Weight: 36628.82
    Molecule: Kelch-like ECH-associated protein 1
    Polymer: 1 Type: protein Length: 316
    Chains: A
    Fragment: keap1-dc, residues 309-624
    Organism Mus musculus
    Gene Names Keap1 Inrf2 Kiaa0132
    UniProtKB:   Protein Feature View | Search PDB | Q9Z2X8  
    Molecule: Nuclear factor erythroid 2 related factor 2
    Polymer: 2 Type: protein Length: 9
    Chains: B
    Fragment: Nrf2/Neh2 peptide, residues 76-84
    Gene Names Nfe2l2 Nrf-2 Nrf2
    UniProtKB:   Protein Feature View | Search PDB | Q60795  
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Mus musculus   Taxonomy   Common Name: House mouse Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Synthetic construct   Taxonomy    
     
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    Identifier Details
    1X2J  Keap1-DC native 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name Interactions
    SO4
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    SULFATE ION
     
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  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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