STRUCTURE-ACTIVITY RELATIONSHIPS IN PURINE-BASED INHIBITOR BINDING TO HSP90 ISOFORMS DOI:10.2210/pdb1uyl/pdb

1UYL   Display Files  close FASTA Sequence PDB File PDB File (Header) mmCIF File mmCIF File (Header) PDBML/XML File PDBML/XML File (Header)   Download Files  close FASTA Sequence PDB File (Text) PDB File (gz) mmCIF File mmCIF File (gz) PDBML/XML File PDBML/XML File (gz) Structure Factor (Text) Structure Factor (gz) Biological Assembly (gz) (A+S)   Share this Page  close Facebook Twitter LinkedIn Email Link this Page

Primary Citation       Related Citations in PDB Entry (REMARK 1) Hide     Molecular Description Hide Classification: Chaperone Structure Weight: 26602.00 Molecule: HEAT SHOCK PROTEIN HSP 90-ALPHA Polymer: 1 Type: protein Length: 236 Chains: A Fragment: N-TERMINAL DOMAIN, RESIDUES 1-235 Organism Homo sapiens Gene Names HSP90AA1 HSP90A HSPC1 HSPCA UniProtKB:   Protein Feature View | Search PDB | P07900         Source Hide Polymer: 1 Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli       Related PDB Entries Hide Identifier Details 1BYQ  HSP90 N-TERMINAL DOMAIN BOUND TO ADP-MG  1OSF  HUMAN HSP90 IN COMPLEX WITH 17-DESMETHOXY- 17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN  1UY6  HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(3,4,5-TRIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE  1UY7  HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(4-METHOXY-BENZYL)-9H-PURIN-6-YLAMINE  1UY8  HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(3-TRIMETHOXY-BENZYL)-9H-PURIN-6YLAMINE  1UY9  HUMAN HSP90-ALPHA WITH 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL- 9H-PURIN-6-YLAMINE  1UYC  HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(2,5-DIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE  1UYD  HUMAN HSP90-ALPHA WITH 9-BUTYL-8- (2-CHLORO-3,4,5-TRIMETHOXY-BENZYL) -9H-PURIN-6-YLAMINE  1UYE  HUMAN HSP90-ALPHA WITH 8-(2-CHLORO-3,4,5-TRIMETHOXY-BENZYL) -9-PENT-4-YLNYL-9H-PURIN-6-YLAMINE  1UYF  HUMAN HSP90-ALPHA WITH 8-(2-CHLORO-3,4,5-TRIMETHOXY-BENZYL) -2-FLUORO-9-PENT-4-YLNYL-9H-PURIN-6-YLAMINE  1UYG  HUMAN HSP90-ALPHA WITH 8-(2,5-DIMETHOXY-BENZYL)-2-FLUORO-9H-PURIN-6-YLAMINE  1UYH  HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(2,5-DIMETHOXY-BENZYL)-2- FLUORO-9H-PURIN-6-YLAMINE  1UYI  HUMAN HSP90-ALPHA WITH 8-(2,5-DIMETHOXY-BENZYL)-2-FLUORO-9- PENT-9H-PURIN-6-YLAMINE  1UYK  HUMAN HSP90-ALPHA WITH 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL -2-FLUORO-9H-PURIN-6-YLAMINE  1UYM  HUMAN HSP90-BETA WITH PU3 (9-BUTYL-8(3,4,5-TRIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE)  1YER  HUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, "CLOSED" CONFORMATION  1YES  HUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, "OPEN" CONFORMATION  1YET  GELDANAMYCIN BOUND TO THE HSP90 GELDANAMYCIN- BINDING DOMAIN      External Domain Annotations Hide SCOP Classification v1.75: 1 Domain - data from SCOP   CATH Classification v3.4.0: 1 Domain - data from CATH   Pfam Classification: 3 Domains - data from Pfam       Structural Biology Knowledgebase Data Hide     Data in orange boxes are gathered from external resources (when available). Reset Layout

Biological Assembly            View in 3D More Images... Biological assembly 1 assigned by authors and generated by PQS (software) Downloadable viewers: Simple Viewer Protein Workshop Ligand Explorer Kiosk Viewer Other Viewers  KiNG WebMol QuickPDB FirstGlance         MyPDB Personal Annotations Hide     Deposition Summary Hide Authors:   Wright, L.,  Barril, X.,  Dymock, B.,  Sheridan, L.,  Surgenor, A.,  Beswick, M.,  Drysdale, M.,  Collier, A.,  Massey, A.,  Davies, N.,  Fink, A.,  Fromont, C.,  Aherne, W.,  Boxall, K.,  Sharp, S.,  Workman, P.,  Hubbard, R.E. Deposition:   2004-03-02 Release:   2004-07-01 Last Modified (REVDAT):   2009-02-24     Revision History    Hide Mouse over text for details 2011-07-13 Version format compliance     Experimental Details Hide Method:   X-RAY DIFFRACTION Exp. Data:   Structure Factors EDS   Resolution[Å]:   1.40 R-Value: 0.200 (obs.) R-Free: 0.227 Space Group: I 2 2 2 Unit Cell:   Length [Å] Angles [°] a = 65.13 α = 90.00  b = 88.77 β = 90.00  c = 99.94 γ = 90.00      Molecule of the Month Hide Hsp90