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HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(2,5-DIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE
1UYC
Primary Citation
 
 
  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Molecular Description Hide
    Classification: Chaperone
    Structure Weight: 26943.41
    Molecule: HEAT SHOCK PROTEIN HSP 90-ALPHA
    Polymer: 1 Type: protein Length: 236
    Chains: A
    Fragment: N-TERMINAL DOMAIN, RESIDUES 1-235
    Organism Homo sapiens
    Gene Names HSP90AA1 HSP90A HSPC1 HSPCA
    UniProtKB:   Protein Feature View | Search PDB | P07900  
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    1BYQ  HSP90 N-TERMINAL DOMAIN BOUND TO ADP-MG 
    1OSF  HUMAN HSP90 IN COMPLEX WITH 17-DESMETHOXY- 17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN 
    1UY6  HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(3,4,5-TRIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE 
    1UY7  HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(4-METHOXY-BENZYL)-9H-PURIN-6-YLAMINE 
    1UY8  HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(3-TRIMETHOXY-BENZYL)-9H-PURIN-6YLAMINE 
    1UY9  HUMAN HSP90-ALPHA WITH 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL- 9H-PURIN-6-YLAMINE 
    1UYD  HUMAN HSP90-ALPHA WITH 9-BUTYL-8- (2-CHLORO-3,4,5-TRIMETHOXY-BENZYL) -9H-PURIN-6-YLAMINE 
    1UYE  HUMAN HSP90-ALPHA WITH 8-(2-CHLORO-3,4,5-TRIMETHOXY-BENZYL) -9-PENT-4-YLNYL-9H-PURIN-6-YLAMINE 
    1UYF  HUMAN HSP90-ALPHA WITH 8-(2-CHLORO-3,4,5-TRIMETHOXY-BENZYL) -2-FLUORO-9-PENT-4-YLNYL-9H-PURIN-6-YLAMINE 
    1UYG  HUMAN HSP90-ALPHA WITH 8-(2,5-DIMETHOXY-BENZYL)-2-FLUORO-9H-PURIN-6-YLAMINE 
    1UYH  HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(2,5-DIMETHOXY-BENZYL)-2- FLUORO-9H-PURIN-6-YLAMINE 
    1UYI  HUMAN HSP90-ALPHA WITH 8-(2,5-DIMETHOXY-BENZYL)-2-FLUORO-9- PENT-9H-PURIN-6-YLAMINE 
    1UYK  HUMAN HSP90-ALPHA WITH 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL -2-FLUORO-9H-PURIN-6-YLAMINE 
    1UYL  STRUCTURE-ACTIVITY RELATIONSHIPS IN PURINE-BASED INHIBITOR BINDING TO HSP90 ISOFORMS 
    1UYM  HUMAN HSP90-BETA WITH PU3 (9-BUTYL-8(3,4,5-TRIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE) 
    1YER  HUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, "CLOSED" CONFORMATION 
    1YES  HUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, "OPEN" CONFORMATION 
    1YET  GELDANAMYCIN BOUND TO THE HSP90 GELDANAMYCIN- BINDING DOMAIN 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name Interactions
    PU7
    Search 
    Download      		PU7 C18 H23 N5 O2
    9-BUTYL-8-(2,5-DIMETHOXY-BENZYL)-9H-PURIN- 6-YLAMINE
    		PU7:1UYC
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    PU7
    Search 
    Download      		PU7
    EC50: 12000 nM (92) - data from BindingDB  
    IC50: 41000 nM (92) - data from BindingDB  
    IC50: 41000 nM - data from BindingMOAD  
    IC50: 41000 nM - data from PDBbind  
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
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  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PQS (software)
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