STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-2 DOI:10.2210/pdb1uu7/pdb

1UU7   Display Files  close FASTA Sequence PDB File PDB File (Header) mmCIF File mmCIF File (Header) PDBML/XML File PDBML/XML File (Header)   Download Files  close FASTA Sequence PDB File (Text) PDB File (gz) mmCIF File mmCIF File (gz) PDBML/XML File PDBML/XML File (gz) Structure Factor (Text) Structure Factor (gz) Biological Assembly (gz) (A+S)   Share this Page  close Facebook Twitter LinkedIn Email Link this Page

Primary Citation       Related Citations in PDB Entry (REMARK 1) Hide     Molecular Description Hide Classification: Transferase Structure Weight: 36690.14 Molecule: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1 Polymer: 1 Type: protein Length: 310 Chains: A EC#: 2.7.11.1    Fragment: KINASE DOMAIN, RESIDUES 51-360 Organism Homo sapiens Gene Names PDPK1 PDK1 UniProtKB:   Protein Feature View | Search PDB | O15530         Source Hide Polymer: 1 Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Spodoptera frugiperda       Related PDB Entries Hide Identifier Details 1H1W  HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN PDK1 CATALYTIC DOMAIN  1OKY  STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE  1OKZ  STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH UCN-01  1UU3  STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH LY333531  1UU8  STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-1  1UU9  STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-3  1UVR  STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-8      Ligand Chemical Component Hide Identifier Formula Name Interactions BI2 Search  Download  C27 H26 N4 O2 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}- 1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE   Ligand Explorer GOL Search  Download  C3 H8 O3 GLYCEROL   Ligand Explorer SO4 Search  Download  O4 S SULFATE ION   Ligand Explorer     External Ligand Annotations Hide Identifier   Binding Affinity (Sequence Identity %) BI2 Search  Download  IC50: 14000 nM (100) - data from BindingDB   IC50: 14000 nM - data from BindingMOAD   IC50: 14000 nM - data from PDBbind       Modified Residues Hide Identifier Formula Parent Type SEP Search  C3 H8 N O6 P SER lPeptideLinking     External Domain Annotations Hide SCOP Classification v1.75: 1 Domain - data from SCOP   CATH Classification v3.4.0: 2 Domains - data from CATH   Pfam Classification: 1 Domain - data from Pfam       Structural Biology Knowledgebase Data Hide     Data in orange boxes are gathered from external resources (when available). Reset Layout

Biological Assembly            View in 3D More Images... Biological assembly 1 assigned by authors and generated by PQS (software) Downloadable viewers: Simple Viewer Protein Workshop Ligand Explorer Kiosk Viewer Other Viewers  KiNG WebMol QuickPDB FirstGlance         MyPDB Personal Annotations Hide     Deposition Summary Hide Authors:   Komander, D.,  Kular, G.S.,  Schuttelkopf, A.W.,  Deak, M.,  Prakash, K.R.,  Bain, J.,  Elliot, M.,  Garrido-Franco, M.,  Kozikowski, A.P.,  Alessi, D.R.,  Van Aalten, D.M.F. Deposition:   2003-12-16 Release:   2004-03-04 Last Modified (REVDAT):   2011-07-13     Revision History    Hide Mouse over text for details 2011-07-13 Version format compliance 2011-07-13 Flag residual B-value     Experimental Details Hide Method:   X-RAY DIFFRACTION Exp. Data:   Structure Factors EDS   Resolution[Å]:   1.90 R-Value: 0.235 (obs.) R-Free: 0.279 Space Group: P 32 2 1 Unit Cell:   Length [Å] Angles [°] a = 121.95 α = 90.00  b = 121.95 β = 90.00  c = 48.07 γ = 120.00