Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family.
Benz, J., Trachsel, H., Baumann, U.(1999) Structure 7: 671-679
- PubMed: 10404596 
- DOI: https://doi.org/10.1016/s0969-2126(99)80088-4
- Primary Citation of Related Structures:  
1QDE - PubMed Abstract: 
Translation initiation factor 4A (elF4A) is the prototype of the DEAD-box family of proteins. DEAD-box proteins are involved in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Energy from ATP hydrolysis is used to perform RNA unwinding during initiation of mRNA translation. The presence of elF4A is required for the 43S preinitiation complex to bind to and scan the mRNA.
Organizational Affiliation: 
Departement für Chemie und Biochemie, Universität Bern, Germany. joerg.benz@ibc.unibe.ch