Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine antifolate Complex with Human Dihydrofolate Reductase DOI:10.2210/pdb1pd9/pdb

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Primary Citation       Related Citations in PDB Entry (REMARK 1) Hide     Molecular Description Hide Classification: Oxidoreductase Structure Weight: 21926.25 Molecule: Dihydrofolate reductase Polymer: 1 Type: protein Length: 186 Chains: A EC#: 1.5.1.3    Organism Homo sapiens Gene Name DHFR UniProtKB:   Protein Feature View | Search PDB | P00374         Source Hide Polymer: 1 Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli       Related PDB Entries Hide Identifier Details 1PD8    1PDB        Ligand Chemical Component Hide Identifier Formula Name Interactions CO4 Search  Download  C19 H24 N6 O3 2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY- N-METHYLANILINO)METHYL]PYRIDO[2,3-D]PYRIMIDINE   Ligand Explorer SO4 Search  Download  O4 S SULFATE ION   Ligand Explorer     External Ligand Annotations Hide Identifier   Binding Affinity (Sequence Identity %) CO4 Search  Download  IC50: 0.85 - 200 nM (89 - 100) - data from BindingDB   N/A in BindingMoad N/A in PDBbind     External Domain Annotations Hide SCOP Classification v1.75: 1 Domain - data from SCOP   CATH Classification v3.4.0: 1 Domain - data from CATH   Pfam Classification: 1 Domain - data from Pfam   GO Terms: 25 Terms - data from GO      Structural Biology Knowledgebase Data Hide     Data in orange boxes are gathered from external resources (when available). Reset Layout

Biological Assembly            View in 3D More Images... Biological assembly 1 assigned by authors Downloadable viewers: Simple Viewer Protein Workshop Ligand Explorer Kiosk Viewer Other Viewers  KiNG WebMol QuickPDB FirstGlance         MyPDB Personal Annotations Hide     Deposition Summary Hide Authors:   Cody, V.,  Luft, J.R.,  Pangborn, W.,  Gangjee, A. Deposition:   2003-05-19 Release:   2003-12-09 Last Modified (REVDAT):   2009-02-24     Revision History    Hide Mouse over text for details 2011-07-13 Version format compliance     Experimental Details Hide Method:   X-RAY DIFFRACTION Exp. Data:   Structure Factors EDS   Resolution[Å]:   2.20 R-Value: 0.213 (obs.) R-Free: 0.213 Space Group: H 3 Unit Cell:   Length [Å] Angles [°] a = 85.43 α = 90.00  b = 85.43 β = 90.00  c = 78.36 γ = 120.00      Molecule of the Month Hide Dihydrofolate Reductase