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Crystal structure of binary complex of the catalytic domain of human phenylalanine hydroxylase with dihydrobiopterin (BH2)
 
 
DOI:10.2210/pdb1lrm/pdb
1LRM
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Oxidoreductase
    Structure Weight: 37896.98
     
    Molecule:Phenylalanine-4-hydroxylase
    Polymer:1Type:polypeptide(L)Length:325
    Chains:A
    EC#:1.14.16.1 Go to IUBMB EC entry  
    Fragment:CATALYTIC DOMAIN (RESIDUES 103-427)
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens Go to NCBI Taxonomy entry Common Name: Human Expression System: Escherichia coli  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1DMW  CATALYTIC DOMAIN OF HUMAN PHENYLALANINE HYDROXYLASE(FE(III)) IN COMPLEX WITH DIHYDROBIOPTERIN 
    1J8T  CATALYTIC DOMAIN OF HUMAN PHENYLALANINE HYDROXYLASE(FE(II)) 
    1J8U  CATALYTIC DOMAIN OF HUMAN PHENYLALANINE HYDROXYLASE(FE(II)) IN COMPLEX WITH TETRAHYDROBIOPTERIN 
    1KW0  CATALYTIC DOMAIN OF HUMAN PHENYLALANINE HYDROXYLASE(FE(II)) IN COMPLEX WITH TETRAHYDROBIOPTERIN AND THIENYLALANINE 
    1PAH  CATALYTIC DOMAIN OF HUMAN PHENYLALANINE HYDROXYLASE(FE(III)) 
    2PAH  CATALYTIC AND TETRAMERIZATION DOMAINS OF HUMAN PHENYLALANINE HYDROXYLASE(FE(III)) 
     
     
  •  
    Move Section Ligand Chemical Component Hide
    Identifier Name Formula Interaction View Links
    FE     FE (III) ION Fe 3DLigand Explorer Link out to Ligand Expos:FE Link out to SuperLigands:FE Link out to SuperHapten:FE
    HBI     7,8-DIHYDROBIOPTERIN C9 H13 N5 O3 3DLigand Explorer Link out to Ligand Expos:HBI Link out to SuperLigands:HBI Link out to SuperHapten:HBI
     
     
  •  
    Move Section Derived Data Hide
     
     
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  •  
    Move Section Deposition Summary Hide
    Authors:   Andersen, O.A.

    Deposition:   2002-05-15
    Release:   2002-06-12
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   Download Structure Factors  [ EDS External Link to EDS ]
    View a histogram of Resolution Resolution[Å]: 2.10
    R-Value: 0.211 (work)
    R-Free: 0.235
    Space Group: C 2 2 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 66.59 α = 90.00 
    b = 108.12 β = 90.00 
    c = 124.17 γ = 90.00