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Catalytic Domain of Human Phenylalanine Hydroxylase (Fe(II)) in Complex with Tetrahydrobiopterin and Thienylalanine
 
 
DOI:10.2210/pdb1kw0/pdb
1KW0
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Oxidoreductase
    Structure Weight: 38070.21
     
    Molecule:Phenylalanine-4-hydroxylase
    Polymer:1Type:polypeptide(L)Length:325
    Chains:A
    EC#:1.14.16.1 Go to IUBMB EC entry  
    Fragment:Catalytic domain (residues 103-427)
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens Go to NCBI Taxonomy entry Common Name: Human Expression System: Escherichia coli  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1DMW  Catalytic domain of human phenylalanine hydroxylase (Fe(III)) in complex with dihydrobiopterin 
    1J8T  Catalytic domain of human phenylalanine hydroxylase (Fe(II)) 
    1J8U  Catalytic domain of human phenylalanine hydroxylase (Fe(II)) in complex with tetrahydrobiopterin 
    1PAH  Catalytic domain of human phenylalanine hydroxylase (Fe(III)) 
    2PAH  Catalytic and tetramerization domains of human phenylalanine hydroxylase (Fe(III)) 
     
     
  •  
    Move Section Ligand Chemical Component Hide
    Identifier Name Formula Interaction View Links
    FE2     FE (II) ION Fe 3DLigand Explorer Link out to Ligand Expos:FE2 Link out to SuperLigands:FE2 Link out to SuperHapten:FE2
    H4B     5,6,7,8-TETRAHYDROBIOPTERIN C9 H15 N5 O3 3DLigand Explorer Link out to Ligand Expos:H4B Link out to SuperLigands:H4B Link out to SuperHapten:H4B
    TIH     BETA(2-THIENYL)ALANINE C7 H9 N O2 S 3DLigand Explorer Link out to Ligand Expos:TIH Link out to SuperLigands:TIH Link out to SuperHapten:TIH
     
     
  •  
    Move Section Modified Residues Hide
    Identifier Name Formula Interaction View Links
    TIH BETA(2-THIENYL)ALANINE (parent: ALA)(type: lPeptideLinking) C7 H9 N O2 S 3D Ligand Explorer Link out to Ligand Expos:TIH Link out to SuperLigands:TIH Link out to SuperHapten:TIH 2D
     
     
  •  
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  •  
    Move Section Deposition Summary Hide
    Authors:   Andersen, O.A.,   Flatmark, T.,   Hough, E.

    Deposition:   2002-01-28
    Release:   2003-01-28
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   Download Structure Factors  [ EDS External Link to EDS ]
    View a histogram of Resolution Resolution[Å]: 2.50
    R-Value: 0.220 (work)
    R-Free: 0.267
    Space Group: C 2 2 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 65.17 α = 90.00 
    b = 106.74 β = 90.00 
    c = 123.44 γ = 90.00