Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions.
Juneau, K., Podell, E., Harrington, D.J., Cech, T.R.(2001) Structure 9: 221-231
- PubMed: 11286889 
- DOI: https://doi.org/10.1016/s0969-2126(01)00579-2
- Primary Citation of Related Structures:  
1HR2 - PubMed Abstract: 
The structure of P4-P6, a 160 nucleotide domain of the self-splicing Tetrahymena thermophila intron, was solved previously. Mutants of the P4-P6 RNA that form a more stable tertiary structure in solution were recently isolated by successive rounds of in vitro selection and amplification.
Organizational Affiliation: 
Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.