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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR
 
 
DOI:10.2210/pdb1gij/pdb
1GIJ
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Transferase
    Structure Weight: 34292.12
     
    Molecule:CELL DIVISION PROTEIN KINASE 2
    Polymer:1Type:polypeptide(L)Length:298
    Chains:A
    EC#:2.7.1.37 Go to IUBMB EC entry  
    Mutation:F82H, L83V, K89T
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens Go to NCBI Taxonomy entry Common Name: Human Expression System: Spodoptera frugiperda  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1GIH  1GIH contains the wild type protein, with different ligand 
    1GII  1GII contains the same mutant protein, without the ligand 
     
     
  •  
    Move Section Ligand Chemical Component Hide
    Identifier Name Formula Interaction View Links
    2PU     1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1- A]ISOINDOL-9-YL)-3-(5-PYRROLIDIN-2
    -YL-1H- PYRAZOL-3-YL)-UREA     		C19 H22 N6 O2 3DLigand Explorer Link out to Ligand Expos:2PU Link out to SuperLigands:2PU Link out to SuperHapten:2PU
     
     
  •  
    Move Section Derived Data Hide
     
     
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  •  
    Move Section Deposition Summary Hide
    Authors:   Ikuta, M.,   Nishimura, S.

    Deposition:   2001-02-06
    Release:   2002-02-06
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   N/A
    View a histogram of Resolution Resolution[Å]: 2.20
    R-Value: 0.239 (obs.)
    R-Free: 0.286
    Space Group: P 21 21 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 74.02 α = 90.00 
    b = 72.07 β = 90.00 
    c = 53.98 γ = 90.00