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THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR
1FVV
Primary Citation
 
 
  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Molecular Description Hide
    Classification: Transferase , Cell Cycle
    Structure Weight: 128588.00
    Molecule: CYCLIN-DEPENDENT KINASE 2
    Polymer: 1 Type: protein Length: 298
    Chains: A, C
    EC#: 2.7.11.22   
    Organism Homo sapiens
    Gene Names CDK2 CDKN2
    UniProtKB:   Protein Feature View | Search PDB | P24941  
    Molecule: CYCLIN A
    Polymer: 2 Type: protein Length: 260
    Chains: B, D
    Organism Homo sapiens
    Gene Names CCNA2 CCN1 CCNA
    UniProtKB:   Protein Feature View | Search PDB | P20248  
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name Interactions
    107
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    Download      		107 C21 H15 N5 O3 S2
    4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)- AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE
    		107:1FVV
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    107
    Search 
    Download      		107
    IC50: 9.7 - 10 nM (100) - data from BindingDB  
    N/Ain BindingMoad
    IC50: 10 nM - data from PDBbind  
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
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  Biological Assembly 1       
Biological assembly 1 assigned by authors and generated by PISA (software)
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