HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR HYMENIALDISINE DOI:10.2210/pdb1dm2/pdb

1DM2   Display Files  close FASTA Sequence PDB File PDB File (Header) mmCIF File mmCIF File (Header) PDBML/XML File PDBML/XML File (Header)   Download Files  close FASTA Sequence PDB File (Text) PDB File (gz) mmCIF File mmCIF File (gz) PDBML/XML File PDBML/XML File (gz) Biological Assembly (gz) (A)   Share this Page  close Facebook Twitter LinkedIn Email Link this Page

Primary Citation       Related Citations in PDB Entry (REMARK 1) Hide     Molecular Description Hide Classification: Cell Cycle Structure Weight: 34549.21 Molecule: CYCLIN-DEPENDENT KINASE 2 Polymer: 1 Type: protein Length: 298 Chains: A EC#: 2.7.11.22    Organism Homo sapiens Gene Names CDK2 CDKN2 UniProtKB:   Protein Feature View | Search PDB | P24941         Source Hide Polymer: 1 Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Spodoptera frugiperda       Ligand Chemical Component Hide Identifier Formula Name Interactions EDO Search  Download  C2 H6 O2 1,2-ETHANEDIOL   Ligand Explorer HMD Search  Download  C11 H10 Br N5 O2 4-(5-AMINO-4-OXO-4H-PYRAZOL-3-YL)-2-BROMO- 4,5,6,7-TETRAHYDRO-3AH-PYRROLO[2,3-C]AZEPIN- 8-ONE   Ligand Explorer     External Ligand Annotations Hide Identifier   Binding Affinity (Sequence Identity %) HMD Search  Download  N/A in BindingDB N/A in BindingMoad IC50: 70 nM - data from PDBbind       External Domain Annotations Hide SCOP Classification v1.75: 1 Domain - data from SCOP   CATH Classification v3.4.0: 2 Domains - data from CATH   Pfam Classification: 2 Domains - data from Pfam   GO Terms: 56 Terms - data from GO      Structural Biology Knowledgebase Data Hide     Data in orange boxes are gathered from external resources (when available). Reset Layout

Biological Assembly            View in 3D More Images... Biological assembly 1 assigned by authors Downloadable viewers: Simple Viewer Protein Workshop Ligand Explorer Kiosk Viewer Other Viewers  KiNG WebMol QuickPDB FirstGlance         MyPDB Personal Annotations Hide     Deposition Summary Hide Authors:   Thunnissen, A.M.,  Kim, S.-H. Deposition:   1999-12-13 Release:   2000-05-31 Last Modified (REVDAT):   2009-02-24     Revision History    Hide Mouse over text for details 2011-07-13 Version format compliance     Experimental Details Hide Method:   X-RAY DIFFRACTION Exp. Data: N/A Resolution[Å]:   2.10 R-Value: 0.192 (obs.) R-Free: 0.267 Space Group: P 21 21 21 Unit Cell:   Length [Å] Angles [°] a = 53.39 α = 90.00  b = 70.67 β = 90.00  c = 72.26 γ = 90.00