Biological implications of a 3 A structure of dimeric antithrombin.
Carrell, R.W., Stein, P.E., Fermi, G., Wardell, M.R.(1994) Structure 2: 257-270
- PubMed: 8087553 
- DOI: https://doi.org/10.1016/s0969-2126(00)00028-9
- Primary Citation of Related Structures:  
1ANT - PubMed Abstract: 
Antithrombin, a member of the serpin family of inhibitors, controls coagulation in human plasma by forming complexes with thrombin and other coagulation proteases in a process greatly accelerated by heparin. The structures of several serpins have been determined but not in their active conformations. We have determined the structure of intact antithrombin in order to study its mechanism of activation, particularly with respect to heparin, and the dysfunctions of this mechanism that predispose individuals to thrombotic disease.
Organizational Affiliation: 
Department of Haematology, University of Cambridge, UK.