Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.[A249965] Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins.[A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure,[L7099] and chronic anal fissure.[L42445] It is also used to induce intraoperative hypotension.[L7099]
Synonyms
1,2,3-propanetrioltrinitrate
NG
1,2,3-propanetriyl nitrate
Glyceroltrinitrat
Glycerol, nitric acid triester
Glycerol trinitrate
Nitroglycerine
Glycerin trinitrate
Nitroglycerin
Nitromed
Nitroglicerina
Trinitrine
Trinitroglycerin
Propane-1,2,3-triyl trinitrate
Glyceroli trinitratis
Glyceryl trinitrate
Nitroglycerol
Trinitroglycerol
Brand Names
Nitro-Time
Tridil Injection 5mg/ml
Nitroglycerin SR
Nitroglycerin In 5% Dextrose Inj.-100mcg/ml
Nitro-bid
Apo-nitroglycerin
Nitroglycerin Transdermal Infusion System
Gonitro
Nitro-dur 0.6
Nitro-dur 0.3 - 60mg/15 Sq Cm, 0.3mg/hr
Nitroglycerin In 5% Dextrose Inj.-200mcg/ml
Transderm-nitro 0.8
Nitro-dur
Nitroglycerin Inj 5mg/ml
Trinipatch 0.4
Nitroglycerin
Nitroglycerin Lingual
Basic Dental Emergency Kit
Nitroglycerin in Dextrose
Nitrong SR Srt 2.6mg
Nitrogard-SR Tab 1mg
Nitro-dur 0.2
Nitroject Inj 1mg/ml
Mylan-nitro Patch 0.8
Nitro-time
Nitrostat
Nitronal
Transderm-nitro 0.4
Rectiv
Nitroglycerin Transdermal Delivery System
Transderm-nitro 0.2
Nitrolingual Spray 0.4mg/eam
Nitroglycerin Slocaps
Minitran - Patch Trd 72mg/26.6 Sq Cm
Nitroglycerin In 5% Dextrose Inj.-400mcg/ml
Nitroglycerin Transdermal System
Mylan-nitro Patch 0.2
Nitroject
Nitro-dur 0.8
Nitrol
Nitroglycerin ER
Mylan-nitro Patch 0.6
Mylan-nitro Patch 0.4
Nitro-dur 0.4
Nitroglycerin Injection USP
Deluxe Dental Emergency Kit
Nitroglycerin In Dextrose
Rho-nitro Pumpspray
Trinipatch 0.6
Nitrolingual Pumpspray
Mylan-nitro Sublingual Spray
Transderm-nitro 0.6
Transderm Nitro
Minitran
NitroMist
Trinipatch 0.2
Nitrolingual
Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.[L7102,L38369,L42320] Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.[L7141] Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension.[L7099] Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.[L42445]
Categories
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
Antianginal Agents
Antihypertensive Agents
Cardiac Therapy
Cardiovascular Agents
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682