Chemical Component Summary

Name10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE
Identifiers10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine
FormulaC21 H24 F3 N3 S
Molecular Weight407.496
TypeNON-POLYMER
Isomeric SMILESCN1CCN(CC1)CCCN2c3ccccc3Sc4c2cc(cc4)C(F)(F)F
InChIInChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3
InChIKeyZEWQUBUPAILYHI-UHFFFAOYSA-N

Chemical Details

Formal Charge0
Atom Count52
Chiral Atom Count0
Bond Count55
Aromatic Bond Count12

Drug Info: DrugBank

DrugBank IDDB00831 
NameTrifluoperazine
Groups
  • investigational
  • approved
DescriptionA phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic.
Synonyms
  • Trifluoperazine
  • Trifluopérazine
  • Trifluoperazina
  • Trifluoperazinum
  • 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine
Brand Names
  • Stelazine Tab 5mg
  • PMS Trifluoperazine Tab 10mg
  • Terfluzine Concentrate
  • Stelabid Forte
  • Terfluzine-10
IndicationFor the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation.
Categories
  • Adrenergic alpha-1 Receptor Antagonists
  • Adrenergic alpha-Antagonists
  • Adrenergic Antagonists
  • Agents that produce hypertension
  • Antiemetics
ATC-CodeN05AB06
CAS number117-89-5

Drug Targets

NameTarget SequencePharmacological ActionActions
Dopamine D2 receptorMDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVF...unknownantagonist
Neuron-specific vesicular protein calcyonMVKLGCSFSGKPGKDPGDQDGAAMDSVPLISPLDISQLQPPLPDQVVIKT...unknownantagonist
Alpha-1A adrenergic receptorMVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILS...unknownantagonist
CalmodulinMADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQ...unknowninhibitor
Troponin C, slow skeletal and cardiac musclesMDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQ...unknown
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL422
PubChem 5566
ChEMBL CHEMBL422
ChEBI CHEBI:45951
CCDC/CSD VICXOV, SAPCUJ