A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.
Synonyms
Teofilina
Theophylline sodium glycinate
Theophylline
Theophyllin
1,3-dimethyl-7H-purine-2,6-dione
1,3-dimethylxanthine
Theophylline anhydrous
Theophylline, anhydrous
Brand Names
Theo-24
Theophylline Rougier Elixir
Theophylline 0.8mg and 5% Dextrose Inj
Apo-theo ER
I D M Expectorant Tab
Theo ER
Theolair SR Tab 300mg
Theo-SR 300 Srt 300mg
Theolair SR Tab 500mg
PMS-theophylline Elixir
Aa-theo LA
Slo-bid 200
Theochron Srt 200mg
Theolair SR Tab 250mg
Theo-dur 200 mg
Theo-dur 300 mg
Theolair Tab 125mg
Theophylline 80mg/15ml
Theophylline Anhydrous
Theophylline 1.6mg and 5% Dextrose Inj
Theophylline Elx
Theo-dur 450 mg
Theochron Srt 100mg
Teva-theophylline SR
Theo-dur 100 mg
Quibron T/SR
Theochron Srt 300mg
Theolair
Theophylline 0.8mg/ml In 5% Dextrose Inj
Idm Tab
Slo-bid 50
Theophylline 4mg and 5% Dextrose Inj
Theophylline Extended Release
Theolair Tab 250mg
Elixophyllin
Theophylline Elixir
Theophylline
Quibron T SR Tab 300mg
Theolair SR Tab 200mg
Pulmophylline Elx
Senophylline
Tedral Tab
Slo-bid 300
Theophylline in Dextrose
Uniphyl
Slo-bid 100
Theophylline(Anhydrous)
Quibron-T
Theophylline (Anhydrous)
Ratio-theo-bronc
Elixir De Theophylline
Indication
For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis.
Categories
Agents that reduce seizure threshold
Alkaloids
Anti-Asthmatic Agents
Autonomic Agents
Bronchodilator Agents
Cardiovascular Agents
Cytochrome P-450 CYP1A2 Substrates
Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP2C8 Substrates
Cytochrome P-450 CYP2D6 Substrates
Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP2E1 Substrates
Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP3A Substrates
Cytochrome P-450 CYP3A4 Substrates
Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682